中国西南部感染与食物特异性免疫球蛋白G之间的关联。
Association between infection and food-specific immunoglobulin G in Southwest China.
作者信息
Liu Ying, Shuai Ping, Liu Yu-Ping, Li Dong-Yu
机构信息
Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China.
出版信息
World J Clin Cases. 2021 Nov 16;9(32):9815-9824. doi: 10.12998/wjcc.v9.i32.9815.
BACKGROUND
() has been found to be associated with extragastrointestinal diseases, possibly including adverse food reactions (such as food allergy or intolerance). However, there are few studies on and food allergy or intolerance, and the results are inconsistent. Food-specific immunoglobulin (Ig) G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between infection and food allergy or intolerance.
AIM
To explore the relationship between infection and food-specific IgG.
METHODS
We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study. infection was detected using the C urea breath test. Food-specific IgG of eggs, milk and wheat in serum was assessed. Subjects were grouped according to positivity, and the positive rates of three kinds of food-specific IgG were compared between the two groups. Multivariable logistic regression analysis was performed to elucidate the association between infection and food-specific IgG.
RESULTS
The total infection rate of was 39.3%, and the total food-specific IgG-positive rates of eggs, milk and wheat were 25.2%, 9.0% and 4.9%, respectively. The infection rate of was higher in males than in females, while the positive rates of food-specific IgG were lower in males than in females. The positive rates of food-specific IgG decreased with age in both males and females. In the -positive groups, the positive rates of food-specific IgG of eggs, milk and wheat were all lower than those in the -negative groups. Multivariate logistic regression analysis revealed that infection was negatively correlated with the food-specific IgG-positive rates of eggs, milk and wheat (odds ratio value of eggs 0.844-0.873, milk 0.741-0.751 and wheat 0.755-0.788, in different models).
CONCLUSION
infection was found to be negatively associated with the food-specific IgG of eggs, milk and wheat in Southwest China.
背景
（）已被发现与胃肠道外疾病有关，可能包括不良食物反应（如食物过敏或不耐受）。然而，关于（）与食物过敏或不耐受的研究较少，且结果不一致。食物特异性免疫球蛋白（Ig）G已被证明与食物过敏或不耐受有关，可作为探索（）感染与食物过敏或不耐受之间相关性的标志物。
目的
探讨（）感染与食物特异性IgG之间的关系。
方法
本研究回顾性分析了2014年2月至2018年12月期间21822名受试者的体检数据。采用C尿素呼气试验检测（）感染。评估血清中鸡蛋、牛奶和小麦的食物特异性IgG。根据（）阳性情况对受试者进行分组，比较两组中三种食物特异性IgG的阳性率。进行多变量逻辑回归分析以阐明（）感染与食物特异性IgG之间的关联。
结果
（）的总感染率为39.3%，鸡蛋、牛奶和小麦的食物特异性IgG总阳性率分别为25.2%、9.0%和4.9%。（）的感染率男性高于女性，而食物特异性IgG的阳性率男性低于女性。男性和女性的食物特异性IgG阳性率均随年龄增长而降低。在（）阳性组中，鸡蛋、牛奶和小麦的食物特异性IgG阳性率均低于（）阴性组。多变量逻辑回归分析显示，（）感染与鸡蛋、牛奶和小麦的食物特异性IgG阳性率呈负相关（不同模型中鸡蛋的比值比为0.844 - 0.873，牛奶为0.741 - 0.751，小麦为0.755 - 0.788）。
结论
在中国西南地区，发现（）感染与鸡蛋、牛奶和小麦的食物特异性IgG呈负相关。
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