Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, SUSTech-PKU Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
New Phytol. 2022 Jun;234(6):1945-1950. doi: 10.1111/nph.17908. Epub 2021 Dec 24.
Plants and microbes coinhabit the earth and have coevolved during environmental changes over time. Root metabolites are the key to mediating the dynamic association between plants and microbes, yet the underlying functions and mechanisms behind this remain largely illusive. Knowledge of metabolite-mediated alteration of the root microbiota in response to environmental stress will open avenues for engineering root microbiotas for improved plant stress resistance and health. Here, we synthesize recent advances connecting environmental stresses, the root metabolome and microbiota, and propose integrated synthetic biology-based strategies for tuning the plant root metabolome in situ for microbe-assisted stress resistance, offering potential solutions to combat climate change. The current limitations, challenges and perspectives for engineering the plant root metabolome for modulating microbiota are collectively discussed.
植物和微生物共同栖息在地球上，并随着时间的推移在环境变化中共同进化。根代谢物是介导植物和微生物之间动态联系的关键，但这背后的功能和机制在很大程度上仍不为人知。了解代谢物介导的根微生物区系对环境胁迫的响应，将为工程化根微生物区系以提高植物的抗胁迫能力和健康水平开辟途径。在这里，我们综合了最近的进展，将环境胁迫、根代谢组和微生物组联系起来，并提出了基于综合合成生物学的策略，用于原位调节植物根代谢组，以实现微生物辅助的抗胁迫能力，为应对气候变化提供潜在的解决方案。本文还共同讨论了用于调节微生物组的植物根代谢组工程的当前限制、挑战和观点。
