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Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.

作者信息

Xu Jian, Palestino Dominguez Mayrel, Alewine Christine

机构信息

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-4264, United States.

出版信息

Cancer Commun (Lond). 2022 Mar;42(3):269-272. doi: 10.1002/cac2.12243. Epub 2021 Dec 8.

DOI:10.1002/cac2.12243
PMID:34877804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8923128/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12be/8923128/38f75ebef772/CAC2-42-269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12be/8923128/38f75ebef772/CAC2-42-269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12be/8923128/38f75ebef772/CAC2-42-269-g001.jpg

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本文引用的文献

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Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors.胰腺癌流行病学：了解生活方式和遗传风险因素的作用。
Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):493-502. doi: 10.1038/s41575-021-00457-x. Epub 2021 May 17.
2
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
3
Molecular characteristics of and mutations in pancreatic ductal adenocarcinoma.胰腺导管腺癌中 和 突变的分子特征。
ESMO Open. 2020 Nov;5(6):e000942. doi: 10.1136/esmoopen-2020-000942.
4
Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation.携带胚系 BRCA1、BRCA2 或 PALB2 突变的胰腺导管腺癌患者的铂类药物反应特征。
Br J Cancer. 2020 Feb;122(3):333-339. doi: 10.1038/s41416-019-0582-7. Epub 2019 Dec 2.
5
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.ID1 介导胰腺癌细胞逃避 TGFβ 肿瘤抑制。
Cancer Discov. 2020 Jan;10(1):142-157. doi: 10.1158/2159-8290.CD-19-0529. Epub 2019 Oct 3.
6
ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma.ID3 促进肝内胆管癌干细胞特征并预测其化疗反应。
Hepatology. 2019 May;69(5):1995-2012. doi: 10.1002/hep.30404. Epub 2019 Mar 8.
7
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.ID3调节MDC1介导的DNA损伤反应以维持基因组稳定性。
Nat Commun. 2017 Oct 12;8(1):903. doi: 10.1038/s41467-017-01051-z.
8
The Id-protein family in developmental and cancer-associated pathways.发育和癌症相关通路中的Id蛋白家族。
Cell Commun Signal. 2017 Jan 25;15(1):7. doi: 10.1186/s12964-016-0161-y.
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Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.预计 2030 年美国癌症发病与死亡人数：甲状腺癌、肝癌和胰腺癌带来的意外负担。
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