腹腔镜袖状胃切除术后病态肥胖患者肠道微生物群的变化。
Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy.
作者信息
Kural Alev, Khan Imran, Seyit Hakan, Caglar Tuba R, Toklu Pınar, Vural Meltem
机构信息
Dr Sadi Konuk Research & Training Hospital, University of Health Sciences Bakırköy, Istanbul, Turkey.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau, People's Republic of China.
出版信息
Future Microbiol. 2022 Jan;17:5-15. doi: 10.2217/fmb-2021-0043. Epub 2021 Dec 8.
Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in , , , and was observed after LSG. In addition to lowering BMI, LSG remodeled gut microbiota composition.
使用药物或节食对病态肥胖进行永久性治疗几乎是不可能的。腹腔镜袖状胃切除术（LSG）正成为一种广泛接受的治疗选择。本研究分析并比较了LSG前后肠道微生物群的组成。共从27名病态肥胖个体的LSG前后收集了54份粪便样本。通过16S扩增子测序对肠道微生物群进行分析。LSG后，患者的BMI显著降低（p<0.001），细菌多样性增加。LSG后还观察到厚壁菌门/拟杆菌门的比例增加。普雷沃氏菌科和韦荣氏菌科在术前样本中占主导地位，但在LSG后显著降低。LSG后观察到 、 、 、 和 显著增加。除了降低BMI外，LSG还重塑了肠道微生物群的组成。
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