Kural Alev, Khan Imran, Seyit Hakan, Caglar Tuba R, Toklu Pınar, Vural Meltem
Dr Sadi Konuk Research & Training Hospital, University of Health Sciences Bakırköy, Istanbul, Turkey.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau, People's Republic of China.
Future Microbiol. 2022 Jan;17:5-15. doi: 10.2217/fmb-2021-0043. Epub 2021 Dec 8.
Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in , , , and was observed after LSG. In addition to lowering BMI, LSG remodeled gut microbiota composition.
使用药物或节食对病态肥胖进行永久性治疗几乎是不可能的。腹腔镜袖状胃切除术（LSG）正成为一种广泛接受的治疗选择。本研究分析并比较了LSG前后肠道微生物群的组成。共从27名病态肥胖个体的LSG前后收集了54份粪便样本。通过16S扩增子测序对肠道微生物群进行分析。LSG后，患者的BMI显著降低（p<0.001），细菌多样性增加。LSG后还观察到厚壁菌门/拟杆菌门的比例增加。普雷沃氏菌科和韦荣氏菌科在术前样本中占主导地位，但在LSG后显著降低。LSG后观察到 、 、 、 和 显著增加。除了降低BMI外，LSG还重塑了肠道微生物群的组成。
