Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China.
Bariatric and Metabolic Diseases Surgery Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China.
BMC Gastroenterol. 2024 Oct 12;24(1):363. doi: 10.1186/s12876-024-03450-1.
Obesity is a growing health concern in China, closely linked to metabolic disorders such as type 2 diabetes. Laparoscopic Sleeve Gastrectomy (LSG) is effective in promoting weight loss and improving metabolic outcomes. Emerging evidence highlights the role of gut microbiota in metabolic regulation, yet the specific alterations in gut microbiota and their association with metabolic changes post-surgery in Chinese patients remain unclear. Understanding these shifts could provide key insights into optimizing treatment strategies for metabolic improvement following bariatric surgery.
Stool samples and clinical data were collected from 30 obese patients before and 6 months after surgery. The composition of the gut microbiota was analyzed through 16S rRNA sequencing, and Spearman correlation analysis was used to determine the association between gut microbiota and clinical indicators.
The analysis of 30 patients showed a significant decrease in Body Mass Index (BMI) (36.75 ± 4.09 kg/m vs 26.37 ± 3.47 kg/m, p < 0.0001). Glucose metabolism, including Hemoglobin A1C levels, improved significantly (6.05 ± 0.96 vs 5.05 ± 0.25, p < 0.0001), and liver function as well as serum lipid levels were also notably improved. LSG increased the richness and composition of gut microbiota in obese patients post-surgery. These changes in gut microbiota were closely associated with improved clinical metabolic parameters.
LSG not only significantly reduces body weight while also alleviating metabolic syndrome and comorbidities by altering gut microbiota.
肥胖是中国日益严重的健康问题，与 2 型糖尿病等代谢紊乱密切相关。腹腔镜袖状胃切除术（LSG）在促进体重减轻和改善代谢结果方面非常有效。新出现的证据强调了肠道微生物群在代谢调节中的作用，但中国患者手术后肠道微生物群的具体变化及其与代谢变化的关系尚不清楚。了解这些变化可以为优化代谢改善的治疗策略提供关键见解。
从 30 名肥胖患者术前和术后 6 个月收集粪便样本和临床数据。通过 16S rRNA 测序分析肠道微生物群的组成，使用 Spearman 相关分析确定肠道微生物群与临床指标之间的关联。
对 30 名患者的分析显示体重指数（BMI）显著下降（36.75±4.09 kg/m 2 与 26.37±3.47 kg/m 2 ，p<0.0001）。葡萄糖代谢，包括糖化血红蛋白水平，显著改善（6.05±0.96 与 5.05±0.25 ，p<0.0001），肝功能和血清脂质水平也显著改善。LSG 增加了肥胖患者术后肠道微生物群的丰富度和组成。肠道微生物群的这些变化与改善的临床代谢参数密切相关。
LSG 通过改变肠道微生物群不仅显著减轻体重，还通过缓解代谢综合征和合并症来减轻体重。
