老年患者化疗前自我报告和客观认知功能测量的年龄相关差异。
Age-related differences in self-report and objective measures of cognitive function in older patients prior to chemotherapy.
机构信息
Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
School of Nursing, University of California, San Francisco, California, USA.
出版信息
Nurs Open. 2022 Mar;9(2):1040-1051. doi: 10.1002/nop2.1141. Epub 2021 Dec 8.
AIM
Evaluate for differences in demographic and clinical characteristics and subjective and objective measures of cognitive function (CF) between younger older adults (YOA, 60-69 years) and older adults (OA, ≥70 years).
DESIGN
Cross-sectional.
METHODS
Older oncology patients (n = 139) completed subjective (Attentional Function Index, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) CF scale) and objective (Montreal Cognitive Assessment, Trail Making Test (TMT) A & B) measures of CF prior to chemotherapy. Data were analyzed using parametric and nonparametric tests.
RESULTS
No differences were found between the two groups for any of the subjective or objective CF measures, except that OA patients had higher TMT B scores. Compared with the general population, OAs had significantly higher EORTC CF scores and YOAs had significantly worse scores for all of the objective tests. Clinically meaningful difference between group differences was found for the TMT B test.
目的
评估年龄在 60-69 岁的较年轻老年人（YOA）和年龄在 70 岁及以上的老年人（OA）之间的人口统计学和临床特征以及认知功能（CF）的主观和客观测量结果的差异。
设计
横断面研究。
方法
在化疗前，老年肿瘤患者（n=139）完成了 CF 的主观（注意力功能指数、欧洲癌症研究和治疗组织生活质量问卷（EORTC）CF 量表）和客观（蒙特利尔认知评估、连线测试（TMT）A 和 B）测量。使用参数和非参数检验对数据进行分析。
结果
在所有的主观或客观 CF 测量中，两组之间没有差异，除了 OA 患者的 TMT B 评分较高。与一般人群相比，OAs 的 EORTC CF 评分明显较高，而 YOAs 在所有客观测试中的得分明显较差。TMT B 测试的组间差异具有临床意义。
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