Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, P. R. China.
Nanoscale. 2022 Jan 6;14(2):361-372. doi: 10.1039/d1nr06128c.
The construction of nanoplatforms with combined photothermal properties and cascading enzymatic activities has become an active area of anticancer research. However, the overheating of photothermal therapy (PTT) and the specific properties of tumor microenvironment (TME) greatly impaired the therapeutic efficiency. Herein, we rationally fabricated a virus-like SiO/CeO/VO (SCV) nanoplatform for 1064 nm near-infrared (NIR) triggered mild-temperature PTT and nanozyme catalytic therapy. Firstly, the virus-like shape of SiO/CeO/VO made it favorable for cell adhesion and improved its phagocytosis in cells, and the SCV generated an effective PTT effect upon 1064 nm laser irradiation. Particularly, the produced VO in TME could be used as a heat shock protein inhibitor to inhibit the expression of heat shock protein 60 (HSP60) to enhance the PTT efficiency. Moreover, the SCV nanozyme exhibited obvious peroxidase-mimic (POD) catalytic activity, which could generate highly toxic free radical ions (˙OH) under acidic conditions. The mild-temperature heat and ˙OH produced by enzymatic catalysis effectively blocked the tumor growth, as verified firmly by and tests. Our designed virus-like SCV nanozyme with POD mimic enzyme activity and a mild photothermal effect may provide a new way of thinking about the combination therapy model.
具有光热特性和级联酶活性的纳米平台的构建已成为癌症治疗研究的活跃领域。然而，光热疗法（PTT）的过热和肿瘤微环境（TME）的特殊性质极大地损害了治疗效率。在此，我们合理地构建了一种病毒样的 SiO/CeO/VO（SCV）纳米平台，用于 1064nm 近红外（NIR）触发的温和温度 PTT 和纳米酶催化治疗。首先，SiO/CeO/VO 的病毒样形状有利于细胞黏附，并提高了其在细胞中的吞噬作用，并且 SCV 在 1064nm 激光照射下产生有效的 PTT 效应。特别地，在 TME 中产生的 VO 可以用作热休克蛋白抑制剂，以抑制热休克蛋白 60（HSP60）的表达，从而提高 PTT 效率。此外，SCV 纳米酶表现出明显的过氧化物酶模拟（POD）催化活性，在酸性条件下可产生高毒性自由基离子（˙OH）。温和温度的热量和酶催化产生的˙OH 有效地阻止了肿瘤的生长，通过和试验得到了有力验证。我们设计的具有 POD 模拟酶活性和温和光热效应的病毒样 SCV 纳米酶可能为组合治疗模型提供了一种新的思路。
