膳食类胡萝卜素摄入量与骨质疏松症：2005-2018 年全国健康与营养调查。
Dietary carotenoid intake and osteoporosis: the National Health and Nutrition Examination Survey, 2005-2018.
机构信息
Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, China.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 232-1163 Xinmin Street, Jilin, 130021, Changchun, China.
出版信息
Arch Osteoporos. 2021 Dec 8;17(1):2. doi: 10.1007/s11657-021-01047-9.
UNLABELLED
Higher intake of β-carotene and β-cryptoxanthin were associated with lower risk of osteoporosis. A very high intake of lutein + zeaxanthin was also associated with lower risk of osteoporosis. These results support the beneficial role of carotenoids on bone health.
PURPOSE
To examine the associations of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin intake with the risk of osteoporosis based on the cross-sectional data from the National Health and Nutrition Examination Survey (NHANES), 2005-2018.
METHODS
This study identified individuals ≥ 50 years old with valid and complete data on carotenoid intake and bone mineral density (BMD). Intake of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin was averaged from two 24-h recall interviews. BMD was measured by dual-energy X-ray absorptiometry (DXA) and converted to T-scores; osteoporosis was defined as a T-score ≤ - 2.5. We used logistic regression models to test the associations between carotenoids and osteoporosis, adjusting for factors such as age, sex, race, and education.
RESULTS
Participants were on average 61.9 years of age, with 57.5% identifying as females. Higher quintiles of β-carotene (odds ratio [OR] for quintile 5 vs. 1:0.33; 95% CI: 0.19-0.59; P for trend = 0.010) and β-cryptoxanthin intake (OR for quintile 5 vs. 1:0.61; 95% CI: 0.39-0.97; P for trend = 0.037) were associated with reduced risk of osteoporosis. Similar and marginally significant results for lutein + zeaxanthin intake was found (OR for quintile 5 vs. 1:0.53; 95% CI: 0.30-0.94; P for trend = 0.076). There was no association of α-carotene and lycopene intake with osteoporosis. These associations did not differ by sex (all P_interaction > 0.05).
CONCLUSIONS
Higher β-carotene and β-cryptoxanthin intake was associated with decreased osteoporosis risk. A very high intake of lutein + zeaxanthin was also associated with lower risk of osteoporosis.
未加标签
β-胡萝卜素和β-隐黄质的摄入量较高与骨质疏松症风险降低有关。叶黄素+玉米黄质的极高摄入量也与骨质疏松症风险降低有关。这些结果支持类胡萝卜素对骨骼健康的有益作用。
目的
基于 2005-2018 年全国健康与营养调查（NHANES）的横断面数据，检查α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素和叶黄素+玉米黄质摄入与骨质疏松症风险之间的关联。
方法
本研究鉴定了年龄在 50 岁以上且类胡萝卜素摄入量和骨矿物质密度（BMD）数据有效且完整的个体。α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素和叶黄素+玉米黄质的摄入量由两次 24 小时回顾性访谈的平均值得出。BMD 通过双能 X 射线吸收法（DXA）测量，并转换为 T 评分；骨质疏松症定义为 T 评分≤-2.5。我们使用逻辑回归模型来检验类胡萝卜素与骨质疏松症之间的关联，同时调整了年龄、性别、种族和教育等因素。
结果
参与者的平均年龄为 61.9 岁，其中 57.5%为女性。β-胡萝卜素摄入量较高的五分位数（五分位数 5 与 1 的比值：0.33；95%CI：0.19-0.59；趋势 P 值=0.010）和β-隐黄质摄入（五分位数 5 与 1 的比值：0.61；95%CI：0.39-0.97；趋势 P 值=0.037）与骨质疏松症风险降低相关。叶黄素+玉米黄质摄入也有类似的、略有统计学意义的结果（五分位数 5 与 1 的比值：0.53；95%CI：0.30-0.94；趋势 P 值=0.076）。α-胡萝卜素和番茄红素摄入与骨质疏松症无关。这些关联在性别之间没有差异（所有 P 交互值均>0.05）。
结论
β-胡萝卜素和β-隐黄质摄入量较高与骨质疏松症风险降低有关。叶黄素+玉米黄质的极高摄入量也与骨质疏松症风险降低有关。
Zotero 插件