Ye Jialu, Cheng Jin, Xiong Ruogu, Chen Haoqi, Huang Siyu, Li Huabin, Pang Jinzhu, Zhang Xuguang, Zhu Huilian
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Mengniu Institute of Nutrition Science, Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot City 011050, China.
Antioxidants (Basel). 2024 Sep 14;13(9):1114. doi: 10.3390/antiox13091114.
Aging and age-related diseases are serious public health issues that are receiving growing attention from researchers. Lutein has a critical function in the prevention and management of these issues. Possible mechanisms mainly include suppressing inflammation and oxidative stress, regulating cell activity, and modulating the levels of toxic substances. In this narrative review paper, we sum up the most current developments in the study of the effects of lutein on aging and five age-related diseases (age-related macular degeneration, cataracts, Alzheimer's disease, Parkinson's disease, and osteoporosis), and fundamental mechanisms are reviewed. The bioavailability of lutein and the strategies to improve its bioavailability are discussed. This piece of work can bring a clearer comprehension of the protective effects of lutein against aging and age-related diseases and can be also helpful for developing lutein as functional food and dietary supplements for these age-related diseases.
衰老及与年龄相关的疾病是严重的公共卫生问题，正受到研究人员越来越多的关注。叶黄素在这些问题的预防和管理中具有关键作用。可能的机制主要包括抑制炎症和氧化应激、调节细胞活性以及调节有毒物质的水平。在这篇叙述性综述论文中，我们总结了叶黄素对衰老及五种与年龄相关疾病（年龄相关性黄斑变性、白内障、阿尔茨海默病、帕金森病和骨质疏松症）影响研究的最新进展，并对其基本机制进行了综述。还讨论了叶黄素的生物利用度及其提高生物利用度的策略。这项工作可以使人们更清楚地理解叶黄素对衰老及与年龄相关疾病的保护作用，也有助于将叶黄素开发为针对这些与年龄相关疾病的功能性食品和膳食补充剂。
