Fujian Medical University Union Hospital, Fuzhou, China; Fuzhou City Second Hospital, Fuzhou, China; The Third Clinical Medical College, Fujian Medical University, China.
Fuzhou City Second Hospital, Fuzhou, China; Fujian Provincial Clinical Medical Research Center for First 339 Aid and Rehabilitation in Orthopaedic Trauma (2020Y2014), China.
Clinics (Sao Paulo). 2024 Jun 13;79:100378. doi: 10.1016/j.clinsp.2024.100378. eCollection 2024.
Lipid metabolism factors may play a role in the development of arthritis and hepatic steatosis and fibrosis. The aim of this study was to explore the potential association between arthritis and hepatic steatosis and liver fibrosis.
The nationally representative sample from the National Health and Nutrition Examination Survey was analyzed, with data on arthritis diagnosis, subtype, and liver status obtained. Liver status was assessed using transient elastography. Hepatic steatosis was defined as a Controlled Attenuation Parameter (CAP) score ≥263 dB/m, and liver fibrosis status was defined as F0‒F4. Logistic regression models and subgroup analyses stratified by sex were used to evaluate the associations. Smooth curve fitting was used to describe the associations.
The present study of 6,840 adults aged 20 years or older found a significant positive correlation between arthritis and CAP in multivariate logistic regression analysis (β = 0.003, 95 % CI 0.001 to 0.0041, p < 0.001). Participants with arthritis had a higher risk of hepatic steatosis (OR = 1.248, 95 % CI 1.036 to 1.504, p = 0.020), particularly those with osteoarthritis or degenerative arthritis, but not rheumatoid arthritis (p = 0.847). The positive correlation was maintained in females (β = 0.004, 95 % CI 0.002 to 0.006, p < 0.001), but not in males. There was no significant relationship between arthritis and liver fibrosis (p = 0.508).
This study indicates that there is a positive correlation between arthritis and hepatic steatosis, particularly in females. Nonetheless, there is no significant relationship between arthritis and the risk of liver fibrosis.
脂代谢因素可能在关节炎和肝脂肪变性及纤维化的发展中起作用。本研究旨在探讨关节炎与肝脂肪变性和肝纤维化之间的潜在关联。
对全国健康和营养调查的具有代表性的样本进行了分析，获取了关节炎诊断、亚型和肝脏状况的数据。使用瞬时弹性成像评估肝脏状况。肝脂肪变性定义为受控衰减参数（CAP）评分≥263 dB/m，肝纤维化状态定义为 F0-F4。使用逻辑回归模型和按性别分层的亚组分析来评估相关性。使用平滑曲线拟合来描述相关性。
本研究对 6840 名年龄在 20 岁或以上的成年人进行了研究，发现关节炎与多元逻辑回归分析中的 CAP 之间存在显著的正相关（β=0.003，95%CI 0.001 至 0.0041，p<0.001）。关节炎患者发生肝脂肪变性的风险更高（OR=1.248，95%CI 1.036 至 1.504，p=0.020），尤其是骨关节炎或退行性关节炎患者，但类风湿关节炎患者则不然（p=0.847）。这种正相关在女性中仍然存在（β=0.004，95%CI 0.002 至 0.006，p<0.001），但在男性中则不然。关节炎与肝纤维化之间无显著相关性（p=0.508）。
本研究表明，关节炎与肝脂肪变性之间存在正相关，尤其是在女性中。然而，关节炎与肝纤维化风险之间没有显著关系。
