Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Sleep Med. 2022 Jan;89:31-47. doi: 10.1016/j.sleep.2021.11.008. Epub 2021 Nov 19.
Systematic reviews on sleep bruxism (SB) as a comorbid condition of other sleep-related disorders are lacking. Such reviews would contribute to the insight of sleep clinicians into the occurrence of SB in patients with other sleep-related disorders, and into the underlying mechanisms of such comorbid associations. This systematic review aimed: 1. to determine the prevalence of SB in adults with other sleep-related disorders; and 2. to determine the associations between SB and other sleep-related disorders, and to explain the underlying mechanisms of these associations.
A systematic search on SB and sleep-related disorders was performed in PubMed, Embase, Cochrane Library, and Web of Science to identify eligible studies published until May 15, 2020. Quality assessment was performed using the Risk of Bias Assessment tool for Non-randomized Studies.
Of the 1539 unique retrieved studies, 37 articles were included in this systematic review. The prevalence of SB in adult patients with obstructive sleep apnea, restless leg syndrome, periodic limb movement during sleep, sleep-related gastroesophageal reflux disease, REM behavior disorder (RBD), and sleep-related epilepsy was higher than that in the general population. The specific mechanisms behind these positive associations could not be identified.
SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson's disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the abovementioned sleep-related disorders.
缺乏关于睡眠磨牙症（SB）作为其他睡眠相关障碍合并症的系统评价。此类综述将有助于睡眠临床医生了解其他睡眠相关障碍患者中 SB 的发生情况，以及这些合并症关联的潜在机制。本系统评价旨在：1. 确定患有其他睡眠相关障碍的成年人中 SB 的患病率；2. 确定 SB 与其他睡眠相关障碍之间的关联，并解释这些关联的潜在机制。
在 PubMed、Embase、Cochrane 图书馆和 Web of Science 上对 SB 和睡眠相关障碍进行了系统检索，以确定截至 2020 年 5 月 15 日发表的合格研究。使用非随机研究的偏倚风险评估工具对质量进行评估。
在 1539 篇独特检索到的研究中，有 37 篇文章被纳入本系统评价。在阻塞性睡眠呼吸暂停、不宁腿综合征、睡眠相关胃食管反流病、快速眼动睡眠行为障碍（RBD）和睡眠相关癫痫的成年患者中，SB 的患病率高于普通人群。这些阳性关联背后的具体机制尚无法确定。
与普通人群相比，SB 在上述疾病患者中更为常见。睡眠觉醒可能是所有已识别的疾病都与之相关的共同因素，除了 RBD 和帕金森病。SB 与这些已识别的睡眠相关障碍之间的关联需要对上述睡眠相关障碍患者进行更多的 SB 筛查。
