Saini S, Stark D D, Brady T J, Wittenberg J, Ferrucci J T
AJR Am J Roentgenol. 1986 Aug;147(2):357-62. doi: 10.2214/ajr.147.2.357.
An animal model of liver cancer was used to demonstrate that with a fast MRI technique, Gadolinium-DTPA increases tumor-liver contrast. A spin-echo pulse sequence with short repetition (TR) and echo-delay (TE) times (TR 250/TE 15/Excitations 1) has a scan time of 0.6 min, which allows early dynamic postcontrast infusion imaging. This is necessary to capture peak compartmental differences when an extracellular contrast agent such as Gadolinium-DTPA is used. This short TR/short TE pulse sequence also increases T1-dependent tissue contrast over the traditional (inversion recovery or spin echo) T1-weighted pulse sequences. Our studies suggest a significant potential for improved detection of liver metastases with Gadolinium-DTPA-enhanced liver MRI.
使用肝癌动物模型来证明，通过快速磁共振成像（MRI）技术，钆喷酸葡胺（Gadolinium-DTPA）可增加肿瘤与肝脏之间的对比度。具有短重复时间（TR）和回波延迟时间（TE）（TR 250/TE 15/激励次数1）的自旋回波脉冲序列扫描时间为0.6分钟，这使得能够进行早期动态造影剂注入后成像。当使用细胞外造影剂如钆喷酸葡胺时，这对于捕捉峰值房室差异是必要的。这种短TR/短TE脉冲序列相比于传统的（反转恢复或自旋回波）T1加权脉冲序列，还增加了T1依赖性组织对比度。我们的研究表明，钆喷酸葡胺增强肝脏MRI在改善肝转移瘤检测方面具有显著潜力。
