鞘脂类和溶血磷脂酸调控肿瘤免疫微环境。

Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid.

机构信息

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Saket Nagar, Bhopal 462020, India.

Department of Medical Devices, National Institute of Pharmaceutical Education & Research- Ahmedabad, Near Air Force Station, Palaj, Gandhinagar-382355, Gujarat, India.

出版信息

Curr Drug Targets. 2022;23(6):559-573. doi: 10.2174/1389450122666211208111833.

DOI:10.2174/1389450122666211208111833

PMID:34879798

Abstract

The tumor microenvironment (TME) consists of cancer cells that interact with stromal components such as the extracellular matrix, blood, and lymphatic networks, fibroblasts, adipocytes, and the cells of the immune system. Further, the tumor immune microenvironment, majorly represented by the tumor-infiltrating immune cells (TIIC), plays an important role in cancer therapeutics and patient prognosis. In fact, a high density of TIICs within the tumor microenvironment is known to be associated with better outcomes in several types of cancers. Towards this, two bioactive lipid molecules, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), regulate the homing of immune cells to the TME. In the present review, we will uncover the role of LPA and S1P signaling in the tumor immune environment, highlighting the latest progress in this field.

摘要

肿瘤微环境（TME）由与细胞外基质、血液和淋巴网络、成纤维细胞、脂肪细胞和免疫系统细胞等基质成分相互作用的癌细胞组成。此外，肿瘤免疫微环境主要由肿瘤浸润免疫细胞（TIIC）组成，在癌症治疗和患者预后中发挥着重要作用。事实上，肿瘤微环境中 TIIC 的高密度与几种类型癌症的更好结果相关。为此，两种生物活性脂质分子，溶血磷脂酸（LPA）和 1-磷酸鞘氨醇（S1P），调节免疫细胞向 TME 的归巢。在本综述中，我们将揭示 LPA 和 S1P 信号在肿瘤免疫环境中的作用，强调该领域的最新进展。