SOHO 最新进展及待解决问题：多发性骨髓瘤老年体弱患者的治疗。
SOHO State of the Art Updates and Next Questions: Treatment of Older, Vulnerable Adults with Multiple Myeloma.
机构信息
Department of Medicine, Division of Hematology, The University of North Carolina at Chapel Hill, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Department of Medicine, Division of Hematology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
出版信息
Clin Lymphoma Myeloma Leuk. 2022 May;22(5):279-286. doi: 10.1016/j.clml.2021.11.003. Epub 2021 Nov 11.
Multiple myeloma is primarily a disease of the elderly, and optimal treatments must weigh the risks of toxicity with the benefits of therapy. Frailty scales have been developed to aid treatment-decision making for older adults with MM. This review provides a framework for incorporating frailty scales into clinical care and highlights how patient-aligned priorities for care can influence the management of older or more vulnerable adults with newly diagnosed multiple myeloma newly diagnosed multiple myeloma. We review the currently available systemic therapies for managing older or more vulnerable adults with newly diagnosed multiple myeloma otherwise considered ineligible for autologous stem cell transplantation.
多发性骨髓瘤主要发生于老年人，在制定治疗方案时必须权衡毒性风险与治疗获益。虚弱评分量表已被开发出来，旨在帮助制定老年多发性骨髓瘤患者的治疗决策。本综述提供了一个将虚弱评分量表纳入临床治疗的框架，并强调了患者对治疗的优先考虑如何影响新诊断的多发性骨髓瘤老年或更脆弱患者的管理。我们综述了目前用于治疗不符合自体干细胞移植条件的新诊断多发性骨髓瘤老年或更脆弱患者的系统治疗方法。
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