Dept. of Public Health, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
BMC Pediatr. 2023 Feb 11;23(1):74. doi: 10.1186/s12887-023-03892-8.
The increasing trend in childhood obesity needs to be closely monitored and intervened due to long-term health issues such as metabolic syndrome, cardiovascular diseases, hypertension, and type 2 diabetes. We aimed to determine and compare the cut-off values for the visceral adiposity index (VAI), triglyceride-glucose index (TyG), and HOMA-IR for predicting metabolic syndrome (MetS).
This population-based cross-sectional study was conducted in May 2019 in Samsun, Turkey. The study included 169 children with obesity aged 9 and 10 years. After anthropometric and clinical evaluation, fasting blood samples were collected from the children. The areas under the curve of the visceral adiposity index, triglyceride-glucose index, and HOMA-IR were compared by receiver-operating-characteristic (ROC) analysis in predicting the MetS.
The total prevalence of MetS was 21.3% in children with obesity, and it was two times higher in girls than in boys. The mean values of TyG and VAI were significantly different in those who have and have not MetS in both genders. However, the HOMA-IR index was higher only in girls with MetS and did not differ in boys by having MetS. The VAI and the TyG index both had statistically significant cut-off values in both sexes and a larger ROC area than the HOMA-IR index in predicting MetS.
The VAI and TyG index are effective indicators in assessing the MetS risk in children with obesity. Both indexes can be considered useful tools in pediatric research and the evaluation of interventions. However, the HOMA-IR index formula needs to be developed taking into account age, gender, and ethnicity.
由于代谢综合征、心血管疾病、高血压和 2 型糖尿病等长期健康问题，儿童肥胖的趋势日益增加，需要密切监测和干预。我们旨在确定和比较内脏脂肪指数（VAI）、甘油三酯-葡萄糖指数（TyG）和 HOMA-IR 用于预测代谢综合征（MetS）的截断值。
本基于人群的横断面研究于 2019 年 5 月在土耳其萨姆松进行。研究纳入了 9 至 10 岁肥胖儿童 169 名。在进行人体测量和临床评估后，从儿童中采集空腹血样。通过受试者工作特征（ROC）分析比较 VAI、TyG 和 HOMA-IR 预测 MetS 的曲线下面积。
肥胖儿童中 MetS 的总患病率为 21.3%，女孩是男孩的两倍。在两性中，患有和不患有 MetS 的儿童的 TyG 和 VAI 平均值差异均有统计学意义。然而，仅患有 MetS 的女孩的 HOMA-IR 指数较高，而患有 MetS 的男孩则没有差异。VAI 和 TyG 指数在两性中均具有统计学显著的截断值，且预测 MetS 的 ROC 面积大于 HOMA-IR 指数。
VAI 和 TyG 指数是评估肥胖儿童 MetS 风险的有效指标。这两个指数都可以被认为是儿科研究和干预评估的有用工具。然而，需要考虑年龄、性别和种族因素来开发 HOMA-IR 指数公式。
