老年患者对新型聚碳酸酯膜的评估及耐受性。初步结果。

Evaluation and tolerance of a new polycarbonate membrane in elderly patients. Preliminary results.

作者信息

Forêt M, Hachache T, Alibeu C, Kuentz F, Meftahi H

出版信息

Blood Purif. 1986;4(1-3):159-67. doi: 10.1159/000169440.

Abstract

We studied the performance and tolerance of a new capillary hemodialyzer using a polycarbonate membrane (Gambrane PCD 1000) in a group of 5 elderly patients (mean age 68 years). The ultrafiltration coefficient is 6 (justifying the monitoring control of weight loss) and clearances for small molecules are comparable with cellulosic membranes. A good tolerance during 300 sessions was observed; nevertheless, an important neutropenia was noted in 2 out of 5 patients. The complement activation measured by the dosage of the C3a Desarg fraction existed in all the patients, reaching an average 6 times the initial level compared to 40 times for Cuprophan. Complement activation and neutropenia are considerably reduced by the reuse of the hemodialyzer as it was described for the cellulosic membranes.

摘要

我们在一组5名老年患者（平均年龄68岁）中研究了一种使用聚碳酸酯膜的新型毛细管血液透析器（Gambrane PCD 1000）的性能和耐受性。超滤系数为6（证明了对体重减轻进行监测控制的合理性），小分子清除率与纤维素膜相当。在300次治疗过程中观察到良好的耐受性；然而，5名患者中有2名出现了严重的中性粒细胞减少。通过测定C3a去精氨酸片段来测量的补体激活在所有患者中均存在，与铜仿膜相比，平均达到初始水平的6倍，而铜仿膜为40倍。如对纤维素膜所描述的那样，血液透析器的再利用可显著降低补体激活和中性粒细胞减少。