Centre Hospitalier Universitaire (CHU) de Guadeloupe, Univ Antilles, Inserm, École des Hautes Études en Santé Publique (EHESP), Irset (Institut de recherche en santé, environnement et travail) -UMR_S 1085, Rennes, France.
Centre Hospitalier Universitaire (CHU) de Rennes, Univ Rennes, Inserm, École des Hautes Études en Santé Publique (EHESP), Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Front Endocrinol (Lausanne). 2021 Nov 22;12:771641. doi: 10.3389/fendo.2021.771641. eCollection 2021.
Chlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties. This organochlorine insecticide was extensively used in the French West Indies from 1973 to 1993 to control the banana root borer. Due to its poor degradation in the environment, permanently polluted soil is responsible for the current contamination of the food chain and human beings. We aimed to examine the relationship of exposure to chlordecone and thyroid (thyroid stimulating hormone [TSH], free tri-iodothyronine [FT3], free thyroxine [FT4]), metabolic (insulin growth-factor 1, leptin, adiponectin), and sex-steroid (dehydroepiandrosterone [DHEA], total testosterone [TT], dihydrotestosterone [DHT], estradiol [E2]) hormone levels in children at the age of seven years who participated in TIMOUN, an ongoing birth cohort in Guadeloupe.
Chlordecone concentrations were measured in cord-blood at delivery. Thyroid, metabolic, and sex-steroid hormone levels were determined in the blood of children at seven years of age. Associations between chlordecone exposure and hormone levels at seven years of age were assessed by multiple linear or logistic regression, controlling for confounding factors.
Among the study population (210 boys and 228 girls), chlordecone and hormone measurements were available for 124 boys and 161 girls. We found the third quartile of chlordecone exposure relative to the lowest quartile to be associated with elevated TSH levels in girls and elevated DHEA, TT, and DHT levels in both sexes. Complementary non-linear analysis (spline regression) confirmed a significant non-linear trend for TSH in girls and DHEA and DHT in boys.
chlordecone exposure was associated with elevated levels of selected thyroid (TSH) and sex-steroid (DHEA, TT, and DHT) hormones at seven years in a non-monotonic dose response (inverted U) relationship. The implications for future health and reproductive function in puberty and adulthood should be determined.
氯丹是一种具有明显雌激素和孕激素特性的内分泌干扰化学物质。这种有机氯杀虫剂于 1973 年至 1993 年在法属西印度群岛被广泛用于控制香蕉根蛀虫。由于其在环境中降解不良，永久性污染的土壤是当前食物链和人类污染的原因。我们旨在研究接触氯丹与甲状腺（促甲状腺激素[TSH]、游离三碘甲状腺原氨酸[FT3]、游离甲状腺素[FT4]）、代谢（胰岛素生长因子 1、瘦素、脂联素）和性激素（脱氢表雄酮[DHEA]、总睾酮[TT]、二氢睾酮[DHT]、雌二醇[E2]）在 7 岁儿童中的关系，这些儿童参加了瓜德罗普岛正在进行的出生队列 TIMOUN。
在分娩时采集脐带血测量氯丹浓度。在 7 岁儿童的血液中测定甲状腺、代谢和性激素水平。通过多元线性或逻辑回归评估氯丹暴露与 7 岁时激素水平之间的关系，同时控制混杂因素。
在所研究的人群（210 名男孩和 228 名女孩）中，有 124 名男孩和 161 名女孩的氯丹和激素测量值可用。我们发现，与最低四分位相比，第三四分位的氯丹暴露与女孩 TSH 水平升高以及两性 DHEA、TT 和 DHT 水平升高相关。补充非线性分析（样条回归）证实了女孩 TSH 和男孩 DHEA 和 DHT 呈显著非线性趋势。
在非单调剂量反应（倒 U 型）关系中，接触氯丹与 7 岁时选定的甲状腺（TSH）和性激素（DHEA、TT 和 DHT）激素水平升高有关。应该确定青春期和成年期对未来健康和生殖功能的影响。
