Multigner Luc, Kadhel Philippe, Rouget Florence, Blanchet Pascal, Cordier Sylvaine
Inserm, U1085 - IRSET, F-97145, Pointe-à-Pitre, Guadeloupe, France.
Université de Rennes 1, F-35700, Rennes, France.
Environ Sci Pollut Res Int. 2016 Jan;23(1):3-8. doi: 10.1007/s11356-015-4621-5. Epub 2015 May 5.
Chlordecone (Kepone) is an organochlorine insecticide that has been used as insecticide and fungicide. In the French West Indies, Guadeloupe and Martinique, it was intensively applied to banana fields from 1973 to 1993 to control root borers. This pesticide undergoes no significant biotic or abiotic degradation in the environment and is still present in soils where it was applied. It was only in 1999 that health and environmental authorities became aware of the extent of the chlordecone pollution of environmental media, including soils, waterways, and the food chain. Earlier observations and toxicological studies have demonstrated that chlordecone is a reproductive and developmental toxicant, neurotoxic and carcinogenic in rodents, and is an endocrine-disrupting chemical because of its estrogenic properties both in vitro and in vivo. Several surveys have confirmed that the French West Indian population continues to be exposed to this chemical though consumption of contaminated foodstuffs. Here, we report the findings of various epidemiological studies conducted in the French West Indies to assess the impact of environmental exposure to chlordecone on the health of the population.
十氯酮（开蓬）是一种有机氯杀虫剂，曾用作杀虫剂和杀菌剂。在法属西印度群岛的瓜德罗普岛和马提尼克岛，1973年至1993年期间，它被大量用于香蕉种植园以防治根蛀虫。这种农药在环境中不会发生显著的生物或非生物降解，至今仍存在于施用过的土壤中。直到1999年，卫生和环境部门才意识到包括土壤、水道和食物链在内的环境介质中十氯酮污染的程度。早期的观察和毒理学研究表明，十氯酮是一种生殖和发育毒性物质，对啮齿动物具有神经毒性和致癌性，并且由于其在体外和体内均具有雌激素特性，所以是一种内分泌干扰化学物质。多项调查证实，法属西印度群岛的居民通过食用受污染的食物仍在持续接触这种化学物质。在此，我们报告在法属西印度群岛进行的各项流行病学研究结果，以评估环境接触十氯酮对人群健康的影响。
