Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
J Am Acad Dermatol. 2023 Oct;89(4):784-794. doi: 10.1016/j.jaad.2021.11.058. Epub 2021 Dec 6.
Dermal white adipose tissue (dWAT) is a dynamic component of the skin and closely interacts with the hair follicle. Interestingly, dWAT envelops the hair follicle during anagen and undergoes fluctuations in volume throughout the hair cycle. dWAT-derived extracellular vesicles can significantly regulate the hair cycle, and this provides a theoretical basis for utilizing adipose tissue as a feasible clinical strategy to treat hair loss. However, the amount and depth of the available literature are far from enough to fully elucidate the prominent role of dWAT in modulating the hair growth cycle. This review starts by investigating the hair cycle-coupled dWAT remodeling and the reciprocal signaling interplay underneath. Then, it summarizes the current literature and assesses the advantages and limitations of clinical research utilizing adipose-derived therapies for hair regeneration.
皮肤白色脂肪组织（dWAT）是皮肤的一个动态组成部分，与毛囊密切相互作用。有趣的是，dWAT 在生长期包裹毛囊，并在整个毛发生长周期中经历体积波动。dWAT 衍生的细胞外囊泡可以显著调节毛发生长周期，这为利用脂肪组织作为治疗脱发的可行临床策略提供了理论依据。然而，现有文献的数量和深度还远远不足以充分阐明 dWAT 在调节毛发生长周期中的突出作用。本综述首先研究了与毛发生长周期相关的 dWAT 重塑及其内部的相互信号作用。然后，它总结了目前的文献，并评估了利用脂肪来源疗法进行头发再生的临床研究的优势和局限性。
