Zhang Yue, Tang Wei, Tian Weidong, Yu Mei
National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024 May 15;38(5):626-632. doi: 10.7507/1002-1892.202402092.
To summarize the dynamic and synchronized changes between the hair cycle and dermal adipose tissue as well as the impact of dermal adipose tissue on hair growth, and to provide a new research idea for the clinical treatment of hair loss.
An extensive review of relevant literature both domestic and international was conducted, analyzing and summarizing the impact of dermal adipose precursor cells, mature dermal adipocytes, and the processes of adipogenesis in dermal adipose tissue on the transition of hair cycle phases.
Dermal adipose tissue is anatomically adjacent to hair follicles and closely related to the changes in the hair cycle. The proliferation and differentiation of dermal adipose precursor cells promote the transition of hair cycle from telogen to anagen, while mature adipocytes can accelerate the transition from anagen to catagen of the hair cycle by expressing signaling molecules, with adipogenesis in dermal adipose tissue and hair cycle transition signaling coexistence.
Dermal adipose tissue affects the transition of the hair cycle and regulates hair growth by secreting various signaling molecules. However, the quantity and depth of existing literature are far from sufficient to fully elucidate its prominent role in regulating the hair cycle, and the specific regulatory mechanisms needs to be further studied.
总结毛发周期与真皮脂肪组织之间的动态同步变化以及真皮脂肪组织对毛发生长的影响，为临床脱发治疗提供新的研究思路。
广泛查阅国内外相关文献，分析总结真皮脂肪前体细胞、成熟真皮脂肪细胞以及真皮脂肪组织中脂肪生成过程对毛发周期各阶段转换的影响。
真皮脂肪组织在解剖学上与毛囊相邻，与毛发周期变化密切相关。真皮脂肪前体细胞的增殖和分化促进毛发周期从休止期向生长期转变，而成熟脂肪细胞可通过表达信号分子加速毛发周期从生长期向退行期转变，真皮脂肪组织中的脂肪生成与毛发周期转换信号并存。
真皮脂肪组织通过分泌多种信号分子影响毛发周期转换并调节毛发生长。然而，现有文献的数量和深度远不足以充分阐明其在调节毛发周期中的突出作用，具体调节机制有待进一步研究。
