VP-1基因的突变导致一种能够在T淋巴母细胞样细胞中生长的猴B淋巴细胞嗜性乳头瘤病毒突变体具有更广泛的宿主范围。
Mutation in the VP-1 gene is responsible for the extended host range of a monkey B-lymphotropic papovavirus mutant capable of growing in T-lymphoblastoid cells.
作者信息
Kanda T, Furuno A, Yoshiike K
出版信息
J Virol. 1986 Aug;59(2):531-4. doi: 10.1128/JVI.59.2.531-534.1986.
Abstract
Monkey B-lymphotropic papovavirus (LPV) replicates only in B-lymphoblastoid cells, whereas the LPV mutant 76 (LPV-76) can grow in either B- or T-lymphoblastoid cells. The nucleotide sequence of the wild-type LPV PstI B segment was compared with that of LPV-76 PstI-B, within which the mutation responsible for the extended host range had been located. The VP-1 coding region of LPV-76 was found to have mutations, single-base substitutions causing three amino acid substitutions.
摘要
猴嗜B淋巴细胞乳头瘤病毒（LPV）仅在B淋巴母细胞中复制，而LPV突变体76（LPV - 76）能够在B或T淋巴母细胞中生长。将野生型LPV PstI B片段的核苷酸序列与LPV - 76 PstI - B的核苷酸序列进行了比较，导致宿主范围扩大的突变就位于LPV - 76 PstI - B中。发现LPV - 76的VP - 1编码区存在突变，即单碱基替换导致三个氨基酸替换。
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