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过氧化物酶体增殖物激活受体 γ-A 因子将代谢不健康的肥胖与胎盘病变联系起来。

PPARγ-A Factor Linking Metabolically Unhealthy Obesity with Placental Pathologies.

机构信息

Clinical Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.

Department of Reproductive Health, Centre of Postgraduate Medical Education St. Sophie's Obstetrics and Gynecology Hospital, 01-004 Warsaw, Poland.

出版信息

Int J Mol Sci. 2021 Dec 6;22(23):13167. doi: 10.3390/ijms222313167.

Abstract

Obesity is a known factor in the development of preeclampsia. This paper links adipose tissue pathologies with aberrant placental development and the resulting preeclampsia. PPARγ, a transcription factor from the ligand-activated nuclear hormone receptor family, appears to be one common aspect of both pathologies. It is the master regulator of adipogenesis in humans. At the same time, its aberrantly low activity has been observed in placental pathologies. Overweight and obesity are very serious health problems worldwide. They have negative effects on the overall mortality rate. Very importantly, they are also conducive to diseases linked to impaired placental development, including preeclampsia. More and more people in Europe are suffering from overweight (35.2%) and obesity (16%) (EUROSTAT 2021 data), some of them young women planning pregnancy. As a result, we will be increasingly encountering obese pregnant women with a considerable risk of placental development disorders, including preeclampsia. An appreciation of the mechanisms shared by these two conditions may assist in their prevention and treatment. Clearly, it should not be forgotten that health education concerning the need for a proper diet and physical activity is of utmost importance here.

摘要

肥胖是子痫前期发展的已知因素。本文将脂肪组织病理学与异常胎盘发育和由此产生的子痫前期联系起来。过氧化物酶体增殖物激活受体γ(PPARγ)是配体激活的核激素受体家族中的转录因子,似乎是这两种病理学的一个共同方面。它是人类脂肪生成的主调节因子。同时,在胎盘病变中观察到其异常低活性。超重和肥胖是全球非常严重的健康问题。它们对总死亡率有负面影响。非常重要的是,它们也有利于与胎盘发育受损相关的疾病,包括子痫前期。欧洲越来越多的人超重(35.2%)和肥胖(16%)(EUROSTAT 2021 年数据),其中一些是计划怀孕的年轻女性。因此,我们将越来越多地遇到肥胖孕妇,她们有相当大的胎盘发育障碍风险,包括子痫前期。了解这两种情况共有的机制可能有助于预防和治疗它们。显然,不应忘记,关于适当饮食和体育锻炼必要性的健康教育在这里至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/8658556/1dba7eabdff1/ijms-22-13167-g001.jpg

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