奥沙斯特林：澳大利亚泥蜂巢相关真菌，sp. CMB-MD14 产生的抗细菌倍半萜 注意，我是根据你提供的任务要求进行翻译的。你所提供的英文原文中存在一处拼写错误，应该是“Australian Mud Dauber Wasp”，而不是“Australian Mud Dauber Wasps”。
Oxandrastins: Antibacterial Meroterpenes from an Australian Mud Dauber Wasp Nest-Associated Fungus, sp. CMB-MD14.
机构信息
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Current address: Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
出版信息
Molecules. 2021 Nov 25;26(23):7144. doi: 10.3390/molecules26237144.
The ethyl acetate extract of an ISP-2 agar cultivation of the wasp nest-associated fungus sp. CMB-MD14 exhibited promising antibacterial activity against vancomycin-resistant enterococci (VRE), with a bioassay guided chemical investigation yielding the new meroterpene, oxandrastin A (), the first andrastin- metabolite with an extra oxygenation at C-2. A culture media optimisation strategy informed a scaled-up rice cultivation that yielded , together with three new oxandrastins B-D (-), two known andrastins C () and F (), and a new meroterpene of the austalide family, isoaustalide F (). Structures of - were assigned based on detailed spectroscopic analysis and chemical interconversion. A GNPS molecular networking analysis of the rice cultivation extract detected the known austalides B (), H (), and H acid (), tentatively identified based on molecular formulae and co-clustering with . That the anti-VRE properties of the CMB-MD14 extract were exclusively attributed to (IC 6.0 µM, MIC 13.9 µM), highlights the importance of the 2-OAc and 3-OAc moieties to the oxandrastin anti-VRE pharmacophore.
蜂房相关真菌 sp. CMB-MD14 的 ISP-2 琼脂培养物的乙酸乙酯提取物对万古霉素耐药肠球菌（VRE）表现出有希望的抗菌活性，生物测定指导的化学研究产生了新的倍半萜 oxandrastin A ()，这是第一个在 C-2 处具有额外氧化的 andrastin 代谢物。一种培养基于优化策略的大规模水稻种植，生产出了，以及三种新的 oxandrastins B-D (-)、两种已知的 andrastins C () 和 F ()，以及一种新的 austalide 家族的 meroterpene，isoaustalide F ()。-的结构是基于详细的光谱分析和化学互变来确定的。对水稻培养提取物的 GNPS 分子网络分析检测到了已知的 austalides B ()、H () 和 H 酸 ()，根据分子式和与 co-clustering 进行了初步鉴定。CMB-MD14 提取物对 VRE 的抗药性仅归因于 （IC 6.0 µM，MIC 13.9 µM），这突出了 2-OAc 和 3-OAc 部分对 oxandrastin 抗 VRE 药效团的重要性。
Zotero 插件