Wu Taizong, Salim Angela A, Capon Robert J
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Org Lett. 2021 Nov 5;23(21):8424-8428. doi: 10.1021/acs.orglett.1c03150. Epub 2021 Oct 12.
A brown rice cultivation of sp. CMB-MRF324 yielded six new meroterpenes, millmerranones A-F (-), and four known analogues, terreulactones A-D (-). Millmerranone A () possesses a unique carbon skeleton bearing a rare cyclic carbonate and undergoes an unprecedented base mediated rearrangement to -millmerranone A (). We also report on an unexpected base rearrangement of to ; a plausible biosynthetic relationship linking , , and ; and acetylcholinesterase inhibitory properties (IC 37 nM to >30 μM).
对稻瘟病菌株CMB-MRF324进行糙米培养，得到了6个新的杂萜类化合物，即米默拉酮A-F（-），以及4个已知类似物，即土曲霉内酯A-D（-）。米默拉酮A（）具有独特的碳骨架，带有罕见的环状碳酸酯，并经历了前所未有的碱介导重排反应生成β-米默拉酮A（）。我们还报道了γ-米默拉酮意外地碱重排生成α-米默拉酮；推测了α-、β-和γ-米默拉酮之间可能的生物合成关系；以及它们的乙酰胆碱酯酶抑制活性（IC50为37 nM至>30 μM）。
