Peng Jixing, Zhang Xiaomin, Wang Wei, Zhu Tianjiao, Gu Qianqun, Li Dehai
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marin Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Mar Drugs. 2016 Jul 14;14(7):131. doi: 10.3390/md14070131.
Three new meroterpenoids, named austalides S-U (1-3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4-14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC50 values of 90 and 99 μM, respectively.
从海绵来源的真菌 Aureolatus HDN14 - 107 的培养物中分离出三种新的半萜类化合物，命名为澳洲内酯 S - U（1 - 3），同时还分离出了十一种已知的澳洲内酯衍生物（4 - 14）。它们的结构，包括绝对构型，是根据核磁共振（NMR）、质谱（MS）数据以及含时密度泛函理论（TDDFT）电子圆二色光谱（ECD）计算确定的。化合物 1 是首例萜烯环与色满环以反式构型稠合的澳洲内酯。化合物 3 和 5 对甲型流感病毒（H1N1）表现出活性，其半数抑制浓度（IC50）值分别为 90 和 99 μM。
