Su Wenhao, Cui Jing, Zeng Runsheng
Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
ChemistryOpen. 2023 Jul;12(7):e202300068. doi: 10.1002/open.202300068.
A novel Ru(phen) Cl -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.
研究了一种新型的Ru(phen)Cl催化的未活化烯烃的自由基氯三氟甲基化反应。将取代的8-氨基喹啉衍生的惰性烯酰胺与托格尼试剂反应，以良好的产率得到了多种含氯的三氟甲基衍生物。该反应在90℃下进行，实验结果表明产物中的氯源来自LiCl。
