五种新的具有细胞毒性的倍半萜类化合物来自 sp.
Five New Terpenes with Cytotoxic Activity from sp.
机构信息
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
出版信息
Molecules. 2021 Nov 29;26(23):7229. doi: 10.3390/molecules26237229.
Five new compounds called Pestalotis A-E (-), comprising three monoterpene-lactone compounds (-), one tetrahydrobenzofuran derivative (), and one sesquiterpene (), were isolated from the EtOAc extract of sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. All compounds were tested for antitumor activity against SW-480, LoVo, HuH-7, and MCF-7. The results showed that compounds and exhibited potent antitumor activity against SW-480, LoVo, and HuH-7 cell lines. Furthermore, compound was assessed against HuH-7, and the results indicated that the rate of apoptosis was dose-dependent.
从 sp. 的乙酸乙酯提取物中分离得到五个新化合物，分别命名为 Pestalotis A-E (-)，包括三个单萜内酯化合物 (-)，一个四氢苯并呋喃衍生物 () 和一个倍半萜 ()。通过分析它们的 NMR、HRMS 和 ECD 光谱，阐明了新化合物的结构，并通过比较实验和计算 ECD 光谱确定了它们的绝对构型。所有化合物均进行了抗肿瘤活性测试，针对 SW-480、LoVo、HuH-7 和 MCF-7 细胞系。结果表明，化合物 和 对 SW-480、LoVo 和 HuH-7 细胞系表现出较强的抗肿瘤活性。此外，还对 HuH-7 进行了化合物 的评估，结果表明凋亡率呈剂量依赖性。
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