School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
Molecules. 2018 Dec 7;23(12):3239. doi: 10.3390/molecules23123239.
A novel sesquiterpene dimer, spirocommiphorfuran A (); two new cadinane sesquiterpenoids, commiphorenes A () and B (); along with three known terpenoids (⁻), were isolated from . The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon⁻carbon bond. Additionally, compounds and exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells.
从 中分离得到了一种新的倍半萜二聚体，螺环commiphorfuran A (); 两种新的卡丹烷倍半萜，commiphorenes A () 和 B (); 以及三种已知的萜类化合物 (⁻)。这些新化合物的结构通过 NMR、HRESIMS、量子化学计算和 X 射线衍射分析进行了表征。化合物 具有 7-氧杂双环[2.2.1]庚烷-2-烯核，代表通过螺环系统融合的第一个 germacrane 型倍半萜二聚体实例。化合物 是一种具有全新碳骨架的新型倍半萜，其特征在于通过碳-碳键在卡丹烷骨架上附加一个碳原子。此外，化合物 和 在正常细胞中表现出可接受的细胞毒性和在癌细胞中的高选择性，特别是在 HepG2 细胞中。
