Agadzhanian M G, Smirnova I N, Sidorova E V
Biull Eksp Biol Med. 1986 Aug;102(8):206-8.
The dependence of the production of antibody-forming cells (AFC) and non-specific immunoglobulin-forming cells (nIFC) on the doses of T-dependent (sheep red blood cells, SRBC) and T-independent (polyvinylpyrrolidone, PVP and pneumococcal polysaccharide SSS III) antigens was investigated. The immunization of BALB/c mice with immunogenic or subimmunogenic doses of SRBC and PVP induced a marked increase in the number of antigen-dependent nIFC. In contrast, the injection of any SSS III doses did not influence the amount of nIFC, although a specific immune response to SSS III was quite obvious. Thus, two T-independent antigens, type II, differ in their ability to induce non-specific immune reactions. The experiments on simultaneous administration of monoclonal anti-Thy-1.2 antibodies and PVP or SSS III to mice have demonstrated that these differences were not related to T-suppressor activity. The possible role of T helpers in the immune response to T-independent antigens is discussed.
研究了抗体形成细胞（AFC）和非特异性免疫球蛋白形成细胞（nIFC）的产生对T依赖性抗原（绵羊红细胞，SRBC）和T非依赖性抗原（聚乙烯吡咯烷酮，PVP和肺炎球菌多糖SSS III）剂量的依赖性。用免疫原性或亚免疫原性剂量的SRBC和PVP免疫BALB/c小鼠，可使抗原依赖性nIFC的数量显著增加。相比之下，尽管对SSS III的特异性免疫反应很明显，但注射任何剂量的SSS III都不会影响nIFC的数量。因此，两种II型T非依赖性抗原诱导非特异性免疫反应的能力不同。给小鼠同时注射单克隆抗Thy-1.2抗体与PVP或SSS III的实验表明，这些差异与T抑制活性无关。文中讨论了T辅助细胞在对T非依赖性抗原的免疫反应中的可能作用。
