Gimmel'farb E I, Agadzhanian M G, Smirnova I N
Biull Eksp Biol Med. 1988 Dec;106(12):702-4.
The influence of unilateral nephrectomy on the degree of humoral immune response to T-independent (polyvinylpyrrolidone, PVP) and T-dependent (sheep red blood cells, SRBC) antigens was studied. The increase in the number in antibody-forming cells (AFC) and nonspecific immunoglobulin-forming cells (nIFC) was investigated by means of the adaptive transfer model. The lethally irradiated recipients were injected with the antigen and also the spleen cells of operated and intact donors. PVP did not induce significant alterations of antibody genesis in mice receiving spleen cells of unilaterally nephrectomized animals comparing with recipients of intact spleen cells. At the same time, the kidney operation induced the increase in the number of AFC and nIFC when the SRBC were used. Hence the activation of humoral immune response induced by kidney operation was related not to the direct activation of B-lymphocytes but to T-cells. The possible causes of this activation were analyzed. Spleen cells of operated animals enhance both specific and antigen-dependent nonspecific immune response.
研究了单侧肾切除对机体针对非T细胞依赖性（聚乙烯吡咯烷酮，PVP）和T细胞依赖性（绵羊红细胞，SRBC）抗原的体液免疫反应程度的影响。通过适应性转移模型研究了抗体形成细胞（AFC）和非特异性免疫球蛋白形成细胞（nIFC）数量的增加情况。对接受致死剂量照射的受体注射抗原以及手术切除一侧肾脏的供体和完整供体的脾细胞。与接受完整脾细胞的受体相比，PVP并未在接受单侧肾切除动物脾细胞的小鼠中引起抗体生成的显著改变。同时，当使用SRBC时，肾脏手术导致AFC和nIFC数量增加。因此，肾脏手术诱导的体液免疫反应激活并非与B淋巴细胞的直接激活有关，而是与T细胞有关。分析了这种激活的可能原因。手术动物的脾细胞增强了特异性和抗原依赖性非特异性免疫反应。
