Megrabian T B, Agadzhanian M G, Zaritskaia L S, Sidorova E V
Biull Eksp Biol Med. 1985 Oct;100(10):451-4.
Immunization of BALB/c and C3H/A mice with T-independent antigens (Vi-antigen of Salmonella typhi and polyvinyl pyrrolidone PVP350) induces the appearance of both antibody-forming cells (AFC) and a sharp increase in the number of cells forming nonspecific immunoglobulins (nIFC). This effect is not related to mitogenic properties of the antigens. The number of nIFC formed after simultaneous injection of both T-independent antigens does not differ from that of nIFC formed during immunization with each of these antigens alone. Thus, there was no summation of nIFC number after injection of two T-dependent or one T-dependent and one T-independent antigens. The mechanisms of nIFC formation under the influence of T-dependent and T-independent antigens are discussed.
用非T细胞依赖性抗原（伤寒沙门氏菌Vi抗原和聚乙烯吡咯烷酮PVP350）免疫BALB/c和C3H/A小鼠，可诱导抗体形成细胞（AFC）出现，同时形成非特异性免疫球蛋白的细胞（nIFC）数量急剧增加。这种效应与抗原的促有丝分裂特性无关。同时注射两种非T细胞依赖性抗原后形成的nIFC数量与单独用其中任何一种抗原免疫时形成的nIFC数量没有差异。因此，注射两种T细胞依赖性抗原或一种T细胞依赖性抗原和一种非T细胞依赖性抗原后，nIFC数量没有累加。文中讨论了T细胞依赖性抗原和非T细胞依赖性抗原影响下nIFC形成的机制。
