Dai Yucan, Tang Haiqing, Pang Shanshan
School of Life Sciences, Chongqing University, Chongqing, China.
Front Physiol. 2021 Nov 23;12:775648. doi: 10.3389/fphys.2021.775648. eCollection 2021.
Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have linked the complexity of membrane lipids to signal transductions, organelle functions, as well as physiological processes, and human diseases. Recently, crucial roles for membrane lipids in the aging process are beginning to emerge. In this study, we summarized current advances in our understanding of the relationship between membrane lipids and aging with an emphasis on phospholipid species. We surveyed how major phospholipid species change with age in different organisms and tissues, and some common patterns of membrane lipid change during aging were proposed. Further, the functions of different phospholipid molecules in regulating healthspan and lifespan, as well as their potential mechanisms of action, were also discussed.
磷脂是构成脂质双层的主要膜脂。这种基本的细胞结构起到屏障作用，保护细胞免受各种环境损伤，更重要的是，使多种细胞过程能够在亚细胞区室中发生。大量研究已将膜脂的复杂性与信号转导、细胞器功能以及生理过程和人类疾病联系起来。最近，膜脂在衰老过程中的关键作用开始显现。在本研究中，我们总结了目前对膜脂与衰老关系的理解进展，重点是磷脂种类。我们调查了不同生物体和组织中主要磷脂种类如何随年龄变化，并提出了衰老过程中膜脂变化的一些常见模式。此外，还讨论了不同磷脂分子在调节健康寿命和寿命方面的功能及其潜在作用机制。
