Liawrungrueang Wongthawat, Sarasombath Peem, Maihom Titinat, Tantivorawit Waroon, Sugandhavesa Nantawit, Bunmaprasert Torphong
Department of Orthopaedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Ann Med Surg (Lond). 2021 Nov 23;72:103120. doi: 10.1016/j.amsu.2021.103120. eCollection 2021 Dec.
and importance: Forestier's disease, also known as a vertebral ankylosing hyperostosis or Diffuse Idiopathic Skeletal Hyperostosis (DISH), is a non-inflammatory enthesopathy that affects primarily elderly males and ossifies the anterolateral spine while sparing the intervertebral discs and joint spaces, especially at the cervical spine. Forestier's disease has resulted in the growth of large anterior cervical osteophytes that may compress the pharyngoesophageal region, producing dysphagia. However, symptomatic Forestier's disease presenting with dysphagia and cervical myelopathy is rarely observed.
A 48-year-old male presented with progressive dysphagia and cervical myelopathy. Based on the presence of radiographic study, Forestier's disease was suspected. Large anterior cervical osteophytes at C4-C6 levels compressed the pharyngoesophageal structure posteriorly. Multilevel degenerative discs compressing the C4 to C6 spinal cord were also seen on sagittal MRI T2-weighted images. Anterior cervical osteophytectomy with anterior cervical discectomy and fusion (ACDF) were performed. The patient made a complete neurological recovery and had no recurrent symptoms at the 5-year follow-up. The patient was extremely satisfied with this treatment and can improved his quality of life (QOL).
Treatment of symptomatic Forestier's disease with secondary dysphagia and cervical myelopathy is rare evidenced by the dearth of reports on surgical treatment. Surgical intervention appears to be safe, effective, and able to halt disease progression.
Anterior cervical osteophytectomy combined with ACDF with plate fixation is a preferred technique in both neural decompression and swallowing improvement. Surgical intervention, we consider, provides superior results than prolonged non-surgical treatments.
疾病概述及重要性:福里斯特尔病,也称为椎体强直性骨质增生症或弥漫性特发性骨肥厚(DISH),是一种非炎性附着点病,主要影响老年男性,使脊柱前外侧骨化,同时不累及椎间盘和关节间隙,尤其是颈椎。福里斯特尔病可导致颈椎前方出现大的骨赘,可能压迫咽食管区域,引起吞咽困难。然而,出现吞咽困难和颈椎脊髓病症状的福里斯特尔病很少见。
一名48岁男性出现进行性吞咽困难和颈椎脊髓病。基于影像学检查结果,怀疑为福里斯特尔病。C4 - C6水平的颈椎前方大骨赘向后压迫咽食管结构。矢状面MRI T2加权图像上还可见多个退变椎间盘压迫C4至C6脊髓。行颈椎前路骨赘切除术联合颈椎前路椎间盘切除融合术(ACDF)。患者神经功能完全恢复,5年随访无复发症状。患者对该治疗非常满意,生活质量得到改善。
有症状的福里斯特尔病伴继发性吞咽困难和颈椎脊髓病的治疗罕见,手术治疗的报道较少即证明了这一点。手术干预似乎安全、有效,且能够阻止疾病进展。
颈椎前路骨赘切除术联合带钢板固定的ACDF是神经减压和改善吞咽的首选技术。我们认为,手术干预比长期非手术治疗效果更好。