Department of Neurosurgery at the Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
College of Electrical Engineering, Zhejiang University, Hangzhou, China.
Bioelectromagnetics. 2022 Jan;43(1):40-46. doi: 10.1002/bem.22382. Epub 2021 Dec 9.
The purpose of the present study was to fabricate a volume coil for proton/deuterium magnetic resonance imaging (MRI) in rodents at 9.4 T. Two birdcage radiofrequency (RF) coils have been designed for proton/deuterium MRI: the rungs of two concentric birdcages were azimuthally interleaved with each other for better decoupling, and the two coils were tuned to 400.3 and 61.4 MHz for H/ H resonance at 9.4 T. Compared to a commercially available coil, the proposed H/ H RF coil provides reasonable transmission efficiency and imaging signal-to-noise ratio (SNR); the relationships among imaging parameters such as SNR, voxel size, and deuterium oxide concentrations have been quantitatively studied, and the linear correlation results together with the spectroscopic data in vivo indicate its feasibility in deuterium metabolic imaging (DMI) in vivo. Our study indicates that using the birdcage design for MRI signal excitation combined with surface coil array for signal reception can facilitate DMI investigations more effectively towards future pre-clinical and clinical applications. As a noninvasive method by measuring nonhydrogen nuclear deuterium signals to reflect metabolite information, DMI will feature prominently in future precision medicine through the whole process of diagnosis, treatment, and prognosis. © 2021 Bioelectromagnetics Society.
本研究的目的是为 9.4T 条件下的啮齿类动物质子/氘磁共振成像（MRI）制造体积线圈。设计了两种用于质子/氘 MRI 的鸟笼射频（RF）线圈：两个同心鸟笼的笼条在方位上相互交错以实现更好的去耦，两个线圈调谐到 400.3 和 61.4 MHz 以实现 9.4T 下的 H/H 共振。与市售线圈相比，所提出的 H/H RF 线圈提供了合理的传输效率和成像信噪比（SNR）；定量研究了 SNR、体素大小和重水浓度等成像参数之间的关系，并且体内的光谱数据与线性相关结果表明其在体内氘代谢成像（DMI）中的可行性。我们的研究表明，使用用于 MRI 信号激发的鸟笼设计以及用于信号接收的表面线圈阵列可以更有效地促进未来的临床前和临床 DMI 研究。作为一种通过测量非氢核氘信号来反映代谢物信息的非侵入性方法，DMI 将通过诊断、治疗和预后的全过程在未来的精准医疗中占据重要地位。
