Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas, USA.
Division of Obstetrics and Gynecology, Baylor University Medical Center, Dallas, Texas, USA.
BJOG. 2022 Jun;129(7):1095-1102. doi: 10.1111/1471-0528.17052. Epub 2021 Dec 27.
To assess how absolute uterine factor infertility affects women who undergo uterus transplantation, how uterus transplantation impacts women with absolute uterine factor infertility and how uterus transplant recipients view uterus transplantation in terms of their reproductive autonomy.
Qualitative semi-structured interview study.
Uterus transplant programme in a large academic medical centre in the USA.
POPULATION/SAMPLE: Twenty one uterus transplant recipients.
A medical chart review was conducted to collect patient demographic information and clinical outcomes. Semi-structured interviews collected information regarding participants' experience.
MAIN OUTCOME MEASURE(S): The outcomes of interest were participants' experience of infertility, experience with uterus transplantation and general perceptions of uterus transplantation.
Six participants were pregnant (one with a second child), six had experienced early graft failure and removal, five had delivered a healthy baby, and four had a viable graft and were awaiting embryo transfer. The primary themes identified were: the negative impact of absolute uterine factor infertility diagnosis on psychological wellbeing, relationships and female identity; the positive impact of uterus transplantation on healing the emotional scars of absolute uterine factor infertility, female identity and value of research trial participation and the perception of uterus transplantation as an expansion of reproductive autonomy. All participants reported that uterus transplantation was worthwhile, regardless of individual outcome.
Absolute uterine factor infertility has a negative impact on women from a young age, affects multiple relationships and challenges female identity. Uterus transplantation helps to reverse this impact, transforming women's life narrative of infertility and enhancing female identity.
Absolute uterine factor infertility (AUFI) adversely affects women. Uterus transplantation helps mitigate the negative impact of AUFI, by transforming women's life narratives of infertility and enhancing female identity.
评估绝对子宫因素不孕对接受子宫移植的女性的影响、子宫移植对绝对子宫因素不孕患者的影响，以及子宫移植受者如何看待其生殖自主权与子宫移植的关系。
定性半结构式访谈研究。
美国一家大型学术医疗中心的子宫移植项目。
人群/样本：21 名子宫移植受者。
进行了病历回顾，以收集患者的人口统计学信息和临床结果。半结构式访谈收集了参与者的经验信息。
感兴趣的结果是参与者的不孕经历、子宫移植经历和对子宫移植的一般看法。
6 名参与者怀孕（其中 1 名怀了二胎），6 名经历了早期移植物失败和移除，5 名分娩了健康婴儿，4 名有可存活的移植物，正在等待胚胎移植。确定的主要主题有：绝对子宫因素不孕诊断对心理健康、人际关系和女性身份的负面影响；子宫移植对治愈绝对子宫因素不孕的情感创伤、女性身份和研究试验参与价值的积极影响，以及对子宫移植作为生殖自主权扩展的感知。所有参与者都报告说，无论个人结果如何，子宫移植都是值得的。
绝对子宫因素不孕从年轻时就对女性产生负面影响，影响多种人际关系，挑战女性身份。子宫移植有助于扭转这种影响，改变女性不孕的生活叙述，增强女性身份。
绝对子宫因素不孕（AUFI）对女性有不利影响。子宫移植通过改变女性不孕的生活叙述和增强女性身份，有助于减轻 AUFI 的负面影响。
