Johannesson Liza, Testa Giuliano, Beshara Menas M, da Graca Briget, Walter Jessica R, Quintini Cristiano, Latif Nawar, Hashimoto Koji, Richards Elliott G, O'Neill Kathleen
Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA.
Department of Obstetrics and Gynecology, Baylor University Medical Center, Dallas, TX 75246, USA.
J Clin Med. 2023 Jun 21;12(13):4201. doi: 10.3390/jcm12134201.
This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment.
本研究描述了在美国联系一个正在开展子宫移植（UTx）的活跃项目、表示有兴趣成为子宫移植受者或活体供体的女性的特征。从2015年至2022年7月联系美国三个UTx项目中任何一个项目的女性那里收集了基本人口统计学信息和自我报告的临床信息。在研究期间，这三个中心收到了5194例关于成为UTx受者的咨询。在报告不孕原因的人中，几乎所有报告（4066/4331，94%）都是子宫缺失，要么是先天性缺失（794/4066，20%），要么是子宫切除术后继发缺失（3272/4066，80%）。平均年龄为34岁，49%（2545/5194）的女性在申请时至少有一个孩子。使用活体供体的两个中心收到了2217例关于成为活体供体的咨询。平均年龄为34岁，60%（1330/2217）的女性已生育≥1个孩子。虽然大多数UTx临床试验证据都集中在先天性子宫缺失的年轻女性身上，但这些结果显示，在年龄、不孕原因和生育情况方面，有更广泛的患者群体对此感兴趣。随着该手术从实验阶段过渡到作为临床治疗提供，这些结果引发了关于UTx的适应症和资格标准是否以及应在多大程度上扩大的问题。
