• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

细胞溶解性T淋巴细胞的颗粒含有两种丝氨酸酯酶。

Granules of cytolytic T-lymphocytes contain two serine esterases.

作者信息

Masson D, Nabholz M, Estrade C, Tschopp J

出版信息

EMBO J. 1986 Jul;5(7):1595-600. doi: 10.1002/j.1460-2075.1986.tb04401.x.

DOI:10.1002/j.1460-2075.1986.tb04401.x
PMID:3488903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166984/
Abstract

Cytoplasmic granules from cytolytic T-lymphocytes (CTL) contain two proteins which react with the serine esterase-specific affinity label diisopropylfluorophosphate (DFP). One of these is a trypsin-like esterase which consists of two disulfide-linked 35-kd subunits. The other consists of a single 29-kd chain. Both molecules are induced concomitantly with cytolytic activity and perforin activity in a CTL-derived T-cell hybrid.

摘要

细胞溶解性T淋巴细胞（CTL）的细胞质颗粒含有两种可与丝氨酸酯酶特异性亲和标记物二异丙基氟磷酸酯（DFP）发生反应的蛋白质。其中一种是类似胰蛋白酶的酯酶，由两个通过二硫键相连的35kd亚基组成。另一种由一条单一的29kd链组成。在CTL来源的T细胞杂交体中，这两种分子均与细胞溶解活性和穿孔素活性同时被诱导产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/d2fd4d774aef/emboj00170-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/ca20d827b3e6/emboj00170-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/50a7f27fdc34/emboj00170-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/1e3c750919ca/emboj00170-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/d2fd4d774aef/emboj00170-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/ca20d827b3e6/emboj00170-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/50a7f27fdc34/emboj00170-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/1e3c750919ca/emboj00170-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cd4/1166984/d2fd4d774aef/emboj00170-0186-a.jpg

相似文献

1
Granules of cytolytic T-lymphocytes contain two serine esterases.细胞溶解性T淋巴细胞的颗粒含有两种丝氨酸酯酶。
EMBO J. 1986 Jul;5(7):1595-600. doi: 10.1002/j.1460-2075.1986.tb04401.x.
2
Isolation and characterization of a serine esterase from cytolytic T cell granules.细胞毒性T细胞颗粒中一种丝氨酸酯酶的分离与鉴定
Cell. 1986 Oct 24;47(2):183-94. doi: 10.1016/0092-8674(86)90441-1.
3
Biochemical and functional properties of serine esterases in acidic cytoplasmic granules of cytotoxic T lymphocytes.细胞毒性T淋巴细胞酸性细胞质颗粒中丝氨酸酯酶的生化及功能特性
J Immunol. 1987 Oct 1;139(7):2398-405.
4
A family of serine esterases in lytic granules of cytolytic T lymphocytes.细胞毒性T淋巴细胞溶细胞颗粒中的丝氨酸酯酶家族。
Cell. 1987 Jun 5;49(5):679-85. doi: 10.1016/0092-8674(87)90544-7.
5
Serine esterase and hemolytic activity in human cloned cytotoxic T lymphocytes.人克隆细胞毒性T淋巴细胞中的丝氨酸酯酶与溶血活性
J Exp Med. 1988 Feb 1;167(2):528-40. doi: 10.1084/jem.167.2.528.
6
Serine esterase in cytolytic T lymphocytes.细胞毒性T淋巴细胞中的丝氨酸酯酶。
Nature. 1986;322(6081):740-3. doi: 10.1038/322740a0.
7
Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo.体内诱导产生的病毒特异性细胞毒性T淋巴细胞的杀伤机制。
J Virol. 1990 Aug;64(8):3726-33. doi: 10.1128/JVI.64.8.3726-3733.1990.
8
[Cytotoxic molecules, perforin and serine esterase in cytotoxic T lymphocyte].[细胞毒性T淋巴细胞中的细胞毒性分子、穿孔素和丝氨酸酯酶]
Arerugi. 1989 Jan;38(1):41-8.
9
Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro.高度溶细胞的体内致敏细胞毒性T淋巴细胞缺乏溶细胞颗粒和BLT酯酶活性，在体外经原始淋巴细胞转化后，在T细胞生长因子存在的情况下获得这些成分。
J Immunol. 1988 Sep 1;141(5):1429-36.
10
Subcellular localization of perforin and serine esterase in lymphokine-activated killer cells and cytotoxic T cells by immunogold labeling.通过免疫金标记法对穿孔素和丝氨酸酯酶在淋巴因子激活的杀伤细胞和细胞毒性T细胞中的亚细胞定位研究
J Immunol. 1991 Jun 15;146(12):4427-32.

引用本文的文献

1
Pro-inflammatory granzyme K contributes extracellularly to disease.促炎颗粒酶K在细胞外导致疾病。
Front Immunol. 2025 Jun 18;16:1620670. doi: 10.3389/fimmu.2025.1620670. eCollection 2025.
2
Implications of Rectal Cancer Radiotherapy on the Immune Microenvironment: Allies and Foes to Therapy Resistance and Patients' Outcome.直肠癌放疗对免疫微环境的影响：治疗抵抗及患者预后的助力与阻力因素
Cancers (Basel). 2023 Oct 24;15(21):5124. doi: 10.3390/cancers15215124.
3
Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches.

本文引用的文献

1
Detection, identification, and partial characterization of serine proteases and esterases in biological systems.生物系统中丝氨酸蛋白酶和酯酶的检测、鉴定及部分特性分析。
Anal Biochem. 1982 May 1;122(1):58-69. doi: 10.1016/0003-2697(82)90251-2.
2
Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.Nα-对甲苯磺酰-L-赖氨酰氯甲基酮对细胞毒性T淋巴细胞活性的影响。
J Immunol. 1980 Mar;124(3):1028-33.
3
Cell cycle regulation of cloned cytolytic T cells by T cell growth factor: analysis by flow microfluorometry.
推进大疱性类天疱疮的治疗：新型治疗靶点和方法的全面综述。
Clin Rev Allergy Immunol. 2023 Dec;65(3):331-353. doi: 10.1007/s12016-023-08973-1. Epub 2023 Oct 28.
4
Non-cytotoxic functions of CD8 T cells: "repentance of a serial killer".CD8 T 细胞的非细胞毒性功能：“连环杀手的忏悔”。
Front Immunol. 2022 Sep 12;13:1001129. doi: 10.3389/fimmu.2022.1001129. eCollection 2022.
5
Single-cell RNA-seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis.单细胞RNA测序揭示强直性脊柱炎患者自然杀伤细胞亚群改变及细胞毒性分子水平降低。
J Cell Mol Med. 2022 Feb;26(4):1071-1082. doi: 10.1111/jcmm.17159. Epub 2022 Jan 6.
6
Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis.颗粒酶 B 在炎症性疾病中的作用：细胞凋亡、炎症、细胞外基质重塑、上皮-间充质转化和纤维化。
Front Immunol. 2020 Nov 11;11:587581. doi: 10.3389/fimmu.2020.587581. eCollection 2020.
7
Proteases in Pemphigoid Diseases.天疱疮疾病中的蛋白酶。
Front Immunol. 2019 Jun 26;10:1454. doi: 10.3389/fimmu.2019.01454. eCollection 2019.
8
Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.针对难以区分的蛋白酶设计选择性底物、抑制剂和基于活性的探针时面临的新挑战。
FEBS J. 2017 May;284(10):1518-1539. doi: 10.1111/febs.14001. Epub 2017 Jan 29.
9
Characterization of carboxylesterase in skin mucus of Cirrhinus mrigala and its assessment as biomarker of organophosphate exposure.印度鲮皮肤黏液中羧酸酯酶的特性及其作为有机磷暴露生物标志物的评估
Fish Physiol Biochem. 2014 Jun;40(3):635-44. doi: 10.1007/s10695-013-9872-9. Epub 2013 Oct 5.
10
Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway.人类 B 细胞为何分泌颗粒酶 B？对一种新的 B 细胞分化途径的深入了解。
Oncoimmunology. 2012 Nov 1;1(8):1368-1375. doi: 10.4161/onci.22354.
T细胞生长因子对克隆细胞毒性T细胞的细胞周期调控：流式细胞荧光术分析
J Immunol. 1982 Oct;129(4):1407-14.
4
Hybrids between rat lymphoma and mouse T cells with inducible cytolytic activity.具有可诱导细胞溶解活性的大鼠淋巴瘤细胞与小鼠T细胞的杂交细胞。
Nature. 1982 Jul 8;298(5870):170-2. doi: 10.1038/298170a0.
5
Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.来自细胞毒性大鼠大颗粒淋巴细胞肿瘤的纯化细胞质颗粒的细胞溶解活性。
J Exp Med. 1984 Jul 1;160(1):75-93. doi: 10.1084/jem.160.1.75.
6
Activatable esterase activity of murine natural killer cell--YAC tumour cell conjugates.小鼠自然杀伤细胞-YAC肿瘤细胞结合物的可激活酯酶活性。
J Cell Sci. 1984 Dec;72:1-13. doi: 10.1242/jcs.72.1.1.
7
Proteinases of Leishmania mexicana and other flagellate protozoa.墨西哥利什曼原虫及其他鞭毛虫原生动物的蛋白酶
Parasitology. 1982 Feb;84(1):149-55. doi: 10.1017/s003118200005174x.
8
Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.人类中性粒细胞杀菌氧化酶的β-细胞色素成分的亚细胞定位：激活过程中的易位
J Cell Biol. 1983 Jul;97(1):52-61. doi: 10.1083/jcb.97.1.52.
9
The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage.人淋巴细胞介导的自然细胞毒性（NK）对蛋白酶活性的需求：蛋白酶依赖丝氨酸且具有芳香族氨基酸切割特异性的证据。
J Immunol. 1984 Nov;133(5):2647-54.
10
Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.细胞毒性大鼠大颗粒淋巴细胞肿瘤细胞质颗粒的纯化及特性
J Immunol. 1984 Jun;132(6):3197-204.