细胞溶解性T淋巴细胞的颗粒含有两种丝氨酸酯酶。
Granules of cytolytic T-lymphocytes contain two serine esterases.
作者信息
Masson D, Nabholz M, Estrade C, Tschopp J
出版信息
EMBO J. 1986 Jul;5(7):1595-600. doi: 10.1002/j.1460-2075.1986.tb04401.x.
Abstract
Cytoplasmic granules from cytolytic T-lymphocytes (CTL) contain two proteins which react with the serine esterase-specific affinity label diisopropylfluorophosphate (DFP). One of these is a trypsin-like esterase which consists of two disulfide-linked 35-kd subunits. The other consists of a single 29-kd chain. Both molecules are induced concomitantly with cytolytic activity and perforin activity in a CTL-derived T-cell hybrid.
摘要
细胞溶解性T淋巴细胞（CTL）的细胞质颗粒含有两种可与丝氨酸酯酶特异性亲和标记物二异丙基氟磷酸酯（DFP）发生反应的蛋白质。其中一种是类似胰蛋白酶的酯酶，由两个通过二硫键相连的35kd亚基组成。另一种由一条单一的29kd链组成。在CTL来源的T细胞杂交体中，这两种分子均与细胞溶解活性和穿孔素活性同时被诱导产生。
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