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经导管 Myval 心脏瓣膜系统在治疗右心室流出道和管道功能障碍的严重肺动脉瓣反流中的初步经验。

First experiences with Myval Transcatheter Heart Valve System in the treatment of severe pulmonary regurgitation in native right ventricular outflow tract and conduit dysfunction.

机构信息

Department of Pediatric Cardiology, Koç University School of Medicine, Istanbul, Turkey.

Department of Pediatrics, Koç University, Istanbul, Turkey.

出版信息

Cardiol Young. 2022 Oct;32(10):1609-1615. doi: 10.1017/S1047951121004650. Epub 2021 Dec 10.

DOI:10.1017/S1047951121004650
PMID:34889176
Abstract

The rate of morbidity and mortality related to pulmonary regurgitation and pulmonary stenosis are big concerns after the surgery for CHD. Percutaneous pulmonary valve implantation has been established as a less invasive technique compared to surgery with promising results according to long-term follow-up of the patients. There are only two approved valve options for percutaneous pulmonary valve implantation until now, which are Melody (Medtronic, Minneapolis, Minn, USA) and Sapien (Edwards Lifesciences, Irvine, Ca, USA). Both valves have limitations and do not cover entire patient population. Therefore, the cardiologists need more options to improve outcomes with fewer complications in a such promising area. Herein, we present a case series applying for pulmonary position in conduits and native right ventricular outflow tract of a new transcatheter valve system Myval ® which is designed for transcatheter aortic valve implantation procedures. This is the first patient series in which the use of Myvalv in dysfunctional right ventricular outflow tracts is described, after surgical repair of CHD.

摘要

肺动脉瓣反流和肺动脉瓣狭窄相关的发病率和死亡率是先心病手术后的主要关注点。与手术相比,经皮肺动脉瓣植入术是一种创伤较小的技术,根据患者的长期随访结果显示具有良好的效果。直到目前为止,只有两种经皮肺动脉瓣植入术的批准瓣膜选择,即 Melody(美敦力,明尼苏达州明尼阿波利斯)和 Sapien(爱德华兹生命科学公司,加利福尼亚州欧文)。这两种瓣膜都有局限性,不能覆盖整个患者群体。因此,心脏病专家需要更多的选择,以便在这一前景广阔的领域中以更少的并发症改善治疗效果。在此,我们报告了一系列应用于导管和原生右心室流出道的新型经导管瓣膜系统 Myval ® 的病例,该系统专为经导管主动脉瓣植入术设计。这是先心病手术后,首次描述使用 Myvalv 治疗右心室流出道功能障碍的病例系列。

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引用本文的文献

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Transcatheter Pulmonary Valve Implantation in Congenital Heart Diseases: Current Advances and Future Prospectives.先天性心脏病经导管肺动脉瓣植入术:当前进展与未来展望
Children (Basel). 2025 Apr 24;12(5):547. doi: 10.3390/children12050547.
2
Percutaneous Pulmonary Valve Implantation In Native Right Ventricular Outflow Tract Using Myval™ Without Pre-Stenting.在未进行预支架置入的情况下,使用Myval™经皮在天然右心室流出道植入肺动脉瓣。
Health Sci Rep. 2025 Apr 9;8(4):e70598. doi: 10.1002/hsr2.70598. eCollection 2025 Apr.
3
Evaluating the Sapien® XT Valve in Native Right Ventricular Outflow Tracts After Tetralogy of Fallot Repair: Mid- and Long-Term Results.
法洛四联症修复术后在右心室流出道评估Sapien® XT瓣膜:中期和长期结果
Pediatr Cardiol. 2025 Jan 21. doi: 10.1007/s00246-025-03776-x.
4
Multicenter Experience for Early and Mid-Term Outcome of MyVal Transcatheter Pulmonary Valve Implantation.多中心研究:MyVal 经导管肺动脉瓣植入术的早期和中期结果。
Pediatr Cardiol. 2024 Mar;45(3):570-579. doi: 10.1007/s00246-023-03398-1. Epub 2024 Jan 31.
5
Pulmonary valve replacement in a large and tortuous right ventricle outflow tract with a 32 mm Myval valve under local anaesthesia: challenges and technical considerations: a case report.在局部麻醉下使用32毫米Myval瓣膜置换巨大且迂曲的右心室流出道:挑战与技术考量:一例病例报告
Eur Heart J Case Rep. 2023 Aug 2;7(8):ytad322. doi: 10.1093/ehjcr/ytad322. eCollection 2023 Aug.
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Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review.经导管二尖瓣假体的设计变异、植入及结果:一项综述
Front Cardiovasc Med. 2022 Feb 24;8:782278. doi: 10.3389/fcvm.2021.782278. eCollection 2021.