经导管二尖瓣假体的设计变异、植入及结果：一项综述

Sazzad Faizus, Hon Jimmy Kim Fatt, Ramanathan Kollengode, Nah Jie Hui, Ong Zhi Xian, Ti Lian Kah, Foo Roger, Tay Edgar, Kofidis Theo

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore.

Front Cardiovasc Med. 2022 Feb 24;8:782278. doi: 10.3389/fcvm.2021.782278. eCollection 2021.

UNLABELLED

The transcatheter mitral valve prosthesis is ideally suited for patients with inoperable mitral etiology. The transcatheter mitral valve implantation (TMVI) procedure has closely followed the evolution of transcatheter aortic procedures. There are considerable design variations amongst the limited TMVI prostheses currently available, and the implantation profiles of the devices are notably different. This comprehensive review will provide an overview of the current clinically tried TMVI devices with a focused outcome analysis. In addition, we have discussed the various design characteristics of TMVI and its associated failure mode, implantation technology, delivery methods, first-in-man trials, and pivotal trial summary for the synthesis of recent evidence.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021255241, identifier: CRD42021255241.

未标注

经导管二尖瓣假体非常适合二尖瓣病因无法进行手术的患者。经导管二尖瓣植入术（TMVI）的发展紧跟经导管主动脉手术的步伐。目前可用的有限TMVI假体在设计上有很大差异，而且这些装置的植入特征也明显不同。这篇全面综述将概述当前临床试用的TMVI装置，并进行重点结局分析。此外，我们还讨论了TMVI的各种设计特点及其相关的失败模式、植入技术、输送方法、首例人体试验以及关键试验总结，以综合近期证据。