The Ohio State University Wexner Medical Center, Department of Internal Medicine, Columbus, OH.
Division of Hospital Medicine, Columbus, OH.
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):411-417. doi: 10.1182/hematology.2021000275.
Sickle cell disease is a disorder characterized by chronic hemolytic anemia and multiorgan disease complications. Although vaso-occlusive episodes, acute chest syndrome, and neurovascular disease frequently result in complication and have well-documented guidelines for management, the management of chronic hemolytic and vascular-related complications, such as priapism, leg ulcers, and pulmonary hypertension, is not as well recognized despite their increasing reported prevalence and association with morbidity and mortality. This chapter therefore reviews the current updates on diagnosis and management of priapism, leg ulcers, and pulmonary hypertension.
镰状细胞病是一种以慢性溶血性贫血和多器官疾病并发症为特征的疾病。尽管血管阻塞性发作、急性胸部综合征和神经血管疾病经常导致并发症，并且有明确的管理指南，但慢性溶血性和血管相关并发症的管理，如阴茎异常勃起、腿部溃疡和肺动脉高压，尽管其发病率和死亡率不断增加，但并未得到充分认识。因此，本章回顾了阴茎异常勃起、腿部溃疡和肺动脉高压的诊断和治疗的最新进展。
