Am J Epidemiol. 2022 Mar 24;191(5):834-842. doi: 10.1093/aje/kwab284.
We examined whether secondhand smoke exposure during childhood was associated with cancer mortality in adulthood among never smokers. In the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, we analyzed data from 45,722 Japanese lifetime nonsmokers aged 40-79 years with no history of cancer at baseline (1988-1990) who had completed a lifestyle questionnaire, including information on the number of family members who had smoked at home during their childhood (0, 1, 2, or ≥3 family members). A Cox proportional hazards model and competing-risks regression were used to calculate multivariable hazard ratios and subdistribution hazard ratios with 95% confidence intervals for overall and site-specific cancer mortality according to the number of family members who smoked during the participant's childhood, after adjusting for potentially confounding factors. During a median follow-up period of 19.2 years, a total of 2,356 cancer deaths were documented. Secondhand smoke exposure was positively associated with the risk of mortality from pancreatic cancer in adulthood; the multivariable hazard ratio for having 3 or more family members who smoked (as compared with none) was 2.32 (95% confidence interval: 1.14, 4.72). Associations were not evident for total cancer risk or risk of other types of smoking-related cancer. In this study, secondhand smoke exposure during childhood was associated with an increased risk of pancreatic cancer mortality in adulthood.
我们研究了儿童时期接触二手烟是否与成年后从不吸烟者的癌症死亡率有关。在日本癌症风险评估合作队列研究中，我们分析了来自 45722 名日本终身不吸烟者的数据，这些人在基线时（1988-1990 年）年龄在 40-79 岁之间，没有癌症病史，并且完成了一份生活方式问卷，其中包括他们童年时期家中有多少家庭成员吸烟的信息（0、1、2 或≥3 名家庭成员）。我们使用 Cox 比例风险模型和竞争风险回归来计算多变量风险比和亚分布风险比及其 95%置信区间，以根据参与者童年时期家中吸烟的家庭成员数量，对整体和特定部位癌症死亡率进行调整，以潜在的混杂因素。在中位数为 19.2 年的随访期间，共记录了 2356 例癌症死亡。二手烟暴露与成年后患胰腺癌的死亡风险呈正相关；与没有家庭成员吸烟相比，有 3 个或更多家庭成员吸烟（与没有家庭成员吸烟相比）的多变量风险比为 2.32（95%置信区间：1.14，4.72）。总癌症风险或其他类型与吸烟相关的癌症风险没有明显关联。在这项研究中，儿童时期接触二手烟与成年后患胰腺癌死亡风险增加有关。
