Department of Public Health, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, Japan.
Pancreatology. 2013 May-Jun;13(3):279-84. doi: 10.1016/j.pan.2013.03.015. Epub 2013 Apr 2.
There is uncertainty in the risk of pancreatic cancer with particular aspects of smoking, such as a dose-response relationship and cumulative amount, in Japanese men and women. Very few studies have addressed the role of passive smoking in pancreatic cancer among Japanese women.
We examined the association between active or passive smoking and the risk of death from pancreatic cancer using data from the Japan Collaborative Cohort Study. The cohort participants (46,395 men and 64,190 women) were followed-up for mortality from baseline (1988-1990) through December 31, 2009. Cox proportional hazards regression models were used to estimate relative risks (RR) and 95% confidence intervals (CI).
During follow-up, we recorded 611 pancreatic cancer deaths. After adjustment for potential confounding factors, current smokers had a significantly increased risk of death from pancreatic cancer compared with non-smokers, with an RR of 1.70 (95% CI: 1.33-2.19). The risk of death from pancreatic cancer significantly increased with increasing numbers of cigarettes smoked per day. Exposure to environmental tobacco smoke (ETS) in public spaces was not associated with risk of death from pancreatic cancer. The RR for women who reported ETS exposure was 1.20 (95% CI: 0.87-1.67). Women exposed to ETS during childhood or adolescence had 1.21-fold increased risk, but the association was statistically insignificant.
Cigarette smoking is associated with an approximately 70% increase in the risk of death from pancreatic cancer. Further studies with improved exposure assessment are needed to better quantify the association between passive smoking and pancreatic cancer.
在日本男性和女性中，吸烟的某些方面，如剂量-反应关系和累积量，与胰腺癌风险之间存在不确定性。很少有研究探讨日本女性中被动吸烟在胰腺癌中的作用。
我们使用日本协作队列研究的数据，检查了主动或被动吸烟与胰腺癌死亡风险之间的关联。队列参与者（46395 名男性和 64190 名女性）从基线（1988-1990 年）开始随访至 2009 年 12 月 31 日的死亡率。使用 Cox 比例风险回归模型估计相对风险（RR）和 95%置信区间（CI）。
在随访期间，我们记录了 611 例胰腺癌死亡。调整潜在混杂因素后，与不吸烟者相比，当前吸烟者胰腺癌死亡的风险显著增加，RR 为 1.70（95%CI：1.33-2.19）。胰腺癌死亡风险随着每天吸烟量的增加而显著增加。暴露于公共场所的环境烟草烟雾（ETS）与胰腺癌死亡风险无关。报告暴露于 ETS 的女性的 RR 为 1.20（95%CI：0.87-1.67）。在儿童或青少年时期暴露于 ETS 的女性风险增加 1.21 倍，但关联无统计学意义。
吸烟与胰腺癌死亡风险增加约 70%相关。需要进一步的研究，以改善暴露评估，更好地量化被动吸烟与胰腺癌之间的关联。
