Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Department of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, 305-8575, Japan.
J Public Health (Oxf). 2023 Aug 28;45(3):604-611. doi: 10.1093/pubmed/fdad056.
The main source of secondhand smoke (SHS) exposure during childhood occurs at home due to close family members who smoke. This study examined the association between childhood SHS exposure and the risk of respiratory disease mortality among non-smoking adults.
Data from 44 233 never-smoking Japanese men and women aged 40-79 years who participated in the JACC study between 1988 and 1990 were analyzed. The Cox proportional hazards model was used to calculate hazard ratios and 95% confidence intervals of respiratory disease mortality according to the number of smoking family members during childhood. Subdistribution HRs (SHRs) were calculated as a competing risk analysis.
A total of 735 deaths from respiratory diseases were documented in a median follow-up of 19.2 years. Living with three or more smoking family members during childhood was associated with a higher risk of respiratory disease mortality in adulthood among women; multivariable SHR compared with participants with no family member smokers during childhood was 1.60 (1.01-2.54) for participants with three or more family members who smoked during their childhood.
SHS exposure from three or more family members during childhood was associated with an increased risk of respiratory disease-related mortality in adulthood.
儿童时期二手烟（SHS）暴露的主要来源是家中有吸烟的近亲。本研究旨在探讨儿童时期 SHS 暴露与不吸烟成年人呼吸道疾病死亡风险之间的关系。
本研究分析了 1988 年至 1990 年期间参加 JACC 研究的 44233 名从未吸烟的日本男女的数据。采用 Cox 比例风险模型，根据儿童时期吸烟家庭成员的数量，计算呼吸道疾病死亡率的风险比（HR）和 95%置信区间。采用亚分布 HR（SHR）作为竞争风险分析。
在中位随访 19.2 年期间，共记录了 735 例呼吸道疾病死亡。与儿童时期没有家庭成员吸烟的参与者相比，女性儿童时期与 3 个或更多吸烟家庭成员同住与成年后呼吸道疾病死亡风险增加相关；多变量 SHR 为 1.60（1.01-2.54），儿童时期有 3 个或更多家庭成员吸烟的参与者。
儿童时期来自 3 个或更多家庭成员的 SHS 暴露与成年后呼吸道疾病相关死亡率增加有关。
