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在无胸腺（裸）小鼠、B细胞缺陷（xid）小鼠和脾切除小鼠中诱导早期内毒素耐受性。

Induction of early-phase endotoxin tolerance in athymic (nude) mice, B-cell-deficient (xid) mice, and splenectomized mice.

作者信息

Madonna G S, Vogel S N

出版信息

Infect Immun. 1986 Sep;53(3):707-10. doi: 10.1128/iai.53.3.707-710.1986.

DOI:10.1128/iai.53.3.707-710.1986
PMID:3488965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260853/
Abstract

Early-phase endotoxin tolerance was inducible in mice which were T cell deficient (nude), B cell deficient (xid), or asplenic, which suggests that these lymphoid cell subsets and the spleen do not contribute significantly to the induction of acquired lipopolysaccharide hyporesponsiveness. C3H/HeJ mice did not exhibit the hematopoietic changes observed in mice made endotoxin tolerant, which suggests that multiple mechanisms may underlie lipopolysaccharide hyporesponsiveness.

摘要

在T细胞缺陷（裸鼠）、B细胞缺陷（xid小鼠）或无脾的小鼠中可诱导早期内毒素耐受，这表明这些淋巴细胞亚群和脾脏对获得性脂多糖低反应性的诱导没有显著贡献。C3H/HeJ小鼠没有表现出在内毒素耐受小鼠中观察到的造血变化，这表明脂多糖低反应性可能有多种机制。

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1
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本文引用的文献

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Bacterial endotoxins: chemical structure, biological activity and role in septicaemia.细菌内毒素：化学结构、生物活性及在败血症中的作用
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Induction of splenic T cell proliferation by lipid A in mice immunized with sheep red blood cells.用绵羊红细胞免疫的小鼠中，脂多糖诱导脾脏T细胞增殖。
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Heterogeneity of Ia expression on normal B cells, neonatal B cells, and on cells from B cell-defective CBA/N mice.正常B细胞、新生B细胞以及B细胞缺陷的CBA/N小鼠来源细胞上Ia表达的异质性。
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4
Use of mice tolerant to lipopolysaccharide to demonstrate requirement of cooperation between macrophages and lymphocytes to generate lipopolysaccharide-induced colony-stimulating factor in vivo.利用对脂多糖耐受的小鼠来证明巨噬细胞与淋巴细胞之间在体内产生脂多糖诱导的集落刺激因子时需要相互协作。
Infect Immun. 1983 Jul;41(1):1-5. doi: 10.1128/iai.41.1.1-5.1983.
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Endotoxin-induced T lymphocyte proliferation.内毒素诱导的T淋巴细胞增殖。
J Immunol. 1983 Apr;130(4):1774-9.
6
The synthesis and secretion of granulocyte-monocyte colony-stimulating activity (CSA) by isolated human monocytes: kinetics of the response to bacterial endotoxin.人单核细胞分离后粒细胞-单核细胞集落刺激活性（CSA）的合成与分泌：对细菌内毒素反应的动力学
J Immunol. 1983 Feb;130(2):800-7.
7
Establishment of an inbred line of mice that express a synergistic immune defect precluding in vitro responses to type 1 and type 2 antigens, B cell mitogens, and a number of T cell-derived helper factors.建立一种近交系小鼠，该小鼠表现出协同免疫缺陷，无法对1型和2型抗原、B细胞有丝分裂原以及多种T细胞衍生的辅助因子产生体外反应。
J Exp Med. 1983 Nov 1;158(5):1401-14. doi: 10.1084/jem.158.5.1401.
8
Genetic control of the susceptibility of C3HeB/FeJ mice to Salmonella typhimurium is regulated by a locus distinct from known salmonella response genes.C3HeB/FeJ小鼠对鼠伤寒沙门氏菌易感性的遗传控制由一个与已知沙门氏菌反应基因不同的基因座调控。
J Immunol. 1983 Dec;131(6):2613-5.
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The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity.CBA/N小鼠品系：一个说明X染色体对免疫影响的实验模型。
Adv Immunol. 1982;33:1-71. doi: 10.1016/s0065-2776(08)60834-2.
10
Release of an endogenous pyrogen in vitro from rabbit mononuclear cells.兔单核细胞在体外释放内源性热原。
J Exp Med. 1967 Aug 1;126(2):357-84. doi: 10.1084/jem.126.2.357.