内毒素诱导产生淀粉样相关血清淀粉样蛋白A蛋白过程中的淋巴细胞。
Lymphoid cells in endotoxin-induced production of the amyloid-related serum amyloid A protein.
作者信息
Rosenstreich D L, McAdam K P
出版信息
Infect Immun. 1979 Jan;23(1):181-3. doi: 10.1128/iai.23.1.181-183.1979.
Abstract
Endotoxin-treated mice exhibit a rapid rise in the level of the serum amyloid A (SAA) protein, but this effect is not observed in endotoxin-resistant C3H/HeJ mice. To evaluate the role of lymphoid cells in the production of SAA protein, C3H/HeJ mice were adoptively transfused with endotoxin-sensitive (C3H/HeN) bone marrow cells. After such adoptive transfer, endotoxin treatment of C3H/HeJ mice resulted in high serum levels of SAA protein. The ability of chimeric mice to make SAA protein correlated with the presence of endotoxin-sensitive B lymphocytes and macrophages. These findings suggest that lymphocytes and/or macrophages play an important role in initiating SAA protein synthesis after endotoxin treatment and suggest a possible mechanism by which chronic infection or inflammation leads to amyloidosis.
摘要
用内毒素处理的小鼠血清淀粉样蛋白A（SAA）水平迅速升高，但在内毒素抗性C3H/HeJ小鼠中未观察到这种效应。为了评估淋巴细胞在SAA蛋白产生中的作用，将内毒素敏感型（C3H/HeN）骨髓细胞过继转移到C3H/HeJ小鼠体内。进行这种过继转移后，用内毒素处理C3H/HeJ小鼠会导致血清中SAA蛋白水平升高。嵌合小鼠产生SAA蛋白的能力与内毒素敏感型B淋巴细胞和巨噬细胞的存在相关。这些发现表明，淋巴细胞和/或巨噬细胞在内毒素处理后启动SAA蛋白合成过程中起重要作用，并提示了慢性感染或炎症导致淀粉样变性的一种可能机制。
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