皮质萎缩与脑室容积之间的关系。
The relationship between cortical atrophy and ventricular volume.
作者信息
Massman P J, Bigler E D, Cullum C M, Naugle R I
出版信息
Int J Neurosci. 1986 Aug;30(1-2):87-99. doi: 10.3109/00207458608985659.
Utilizing volumetric measures of brain morphology, the relationship between cortical atrophy and ventricular dilation was examined in a sample of 59 Alzheimer's Disease patients and 48 closed head injury patients. Correlation matrices were constructed and factor analyses performed in order to elucidate the various relationships. In the Alzheimer Disease sample there appeared to be a moderately strong relationship between cortical atrophy and ventricular volume. However, analyses also lent support to the position that cortical atrophy and ventricular dilation reflect processes which are related yet somewhat independent. Results obtained from the closed head injury sample indicated that focal damage effects were more evident in cortical atrophy measures, while generalized effects were relatively more important in ventricular dilation. Finally, the relationships between neuropsychological performance and various combinations of high and low cortical atrophy and ventricular volume measures were modest.
利用脑形态的体积测量方法，在59例阿尔茨海默病患者和48例闭合性颅脑损伤患者的样本中，研究了皮质萎缩与脑室扩张之间的关系。构建了相关矩阵并进行了因子分析，以阐明各种关系。在阿尔茨海默病样本中，皮质萎缩与脑室体积之间似乎存在中等强度的关系。然而，分析也支持了这样一种观点，即皮质萎缩和脑室扩张反映了相关但又有些独立的过程。从闭合性颅脑损伤样本中获得的结果表明，局灶性损伤效应在皮质萎缩测量中更为明显，而全身性效应在脑室扩张中相对更为重要。最后，神经心理学表现与皮质萎缩和脑室体积测量的高低不同组合之间的关系不大。
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