Knockdown of inhibits the differentiation of both intramuscular and subcutaneous preadipocytes in goat.

elongs to the Krüppel-like factors (KLFs) family, which function as transcriptional regulators controlling a number of basic cellular processes, involving proliferation, differentiation, and migration. Here, we reveal insights into the differentiated expression of in different goat tissues and different stages of growth, and the inhibition role of knockdown to differentiation by using goat intramuscular and subcutaneous preadipocytes. We demonstrate that expression is obviously changed during the differentiation of preadipocytes into mature adipocytes. Knockdown of inhibited lipid droplet accumulation, reduced the expression of adipogenic markers both in intramuscular and subcutaneous preadipocytes in goats, suggesting that is a novel regulator of adipogenesis. expression changed also up or down-regulation the other KLF family members, but there were differences between these two types of cells. Investigation into the mechanism that regulates preadipocyte differentiation revealed that KLF family members , , , , , , , and adipogenic markers and promoter region present KLF7 transcriptional binding sites. Altogether, the data here identify as a novel regulator of adipogenesis.