National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, India.
Asian J Psychiatr. 2022 Feb;68:102961. doi: 10.1016/j.ajp.2021.102961. Epub 2021 Dec 2.
One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder. Clinical features of sleep disorders involve various sleep disturbances such as Obstructive Sleep Apnea (OSAS), Excessive Daytime Sleepiness (EDS), Rapid Eye Movement (REM), Breathing Disorders, Periodic limb movements in sleep (PLMS), etc. The primary tools used for the identification of such disturbances are Polysomnography (PSG) and Wrist actigraphy. This review will highlight and explains the different approaches used in the treatment of sleep disorders. Non-pharmacological treatments include Peter Hauri rules, sleep education program, and light therapy which play a key role in the regulation of sleep-wake cycles. Pharmacological therapy described in this article may be useful in treating sleep destruction in patients with Alzheimer's disease. Along with the Non-pharmacological and pharmacological treatment, here we discuss five commonly recognized plant-based nutraceuticals with hypothesized impact on sleep disorders: caffeine, chamomile, cherries, L-tryptophan, and valerian by the proper emphasis on the known mechanism of their action.
阿尔茨海默病患者的合并症之一是睡眠障碍。睡眠障碍的临床特征包括各种睡眠紊乱，如阻塞性睡眠呼吸暂停（OSAS）、日间嗜睡（EDS）、快速眼动（REM）、呼吸障碍、睡眠中周期性肢体运动（PLMS）等。用于识别这些干扰的主要工具是多导睡眠图（PSG）和腕部动作描记法。这篇综述将重点介绍和解释治疗睡眠障碍的不同方法。非药物治疗包括彼得·豪里规则、睡眠教育计划和光照疗法，它们在调节睡眠-觉醒周期中起着关键作用。本文描述的药物治疗可能对治疗阿尔茨海默病患者的睡眠破坏有用。除了非药物和药物治疗外，我们还讨论了五种常见的基于植物的营养保健品，它们被认为对睡眠障碍有影响：咖啡因、洋甘菊、樱桃、色氨酸和缬草，并适当强调了它们作用的已知机制。
