Department of Physics, University of Jaén, Spain.
Department of Experimental Biology, University of Jaén, Spain.
Bioelectrochemistry. 2022 Apr;144:108028. doi: 10.1016/j.bioelechem.2021.108028. Epub 2021 Dec 1.
The surface electrical charge of cells is conditioned by the ionic medium in which they are immersed. This charge is specific for each cell type and is especially important in tumour cells because it determines their state of aggregation and their adhesion in the different organs. This study analyses the variations in surface charge of cells when pH, electrolytes, and their concentration are modified. The modification of these factors leads to changes in the surface charge of tumour cells; therefore, their states of aggregation and behaviour can be modified. This may even have a use in the prognosis and treatment of various tumours. Some studies conclude that the activity associated with the glycolysis process is accompanied by a change in the surface charge of cells. Notably, there is a high rate of glycolysis in tumours. Our results show that surface charge of cells strongly depends on nature of ionic medium in which they are found, with the valence of the majority ion being the most important factor. When ionic strength was high, the charge decreased dramatically. On the other hand, charge becomes zero or positive in an acidic pH, while in a basic pH, the negative charge increases.
细胞的表面电荷受其所处的离子介质条件的影响。这种电荷是每种细胞类型所特有的，在肿瘤细胞中尤为重要，因为它决定了它们的聚集状态和在不同器官中的黏附状态。本研究分析了 pH 值、电解质及其浓度改变时细胞表面电荷的变化。这些因素的改变导致肿瘤细胞表面电荷的改变，因此可以改变它们的聚集状态和行为。这甚至可能在各种肿瘤的预后和治疗中得到应用。一些研究得出结论，与糖酵解过程相关的活动伴随着细胞表面电荷的变化。值得注意的是，肿瘤中糖酵解的速率很高。我们的结果表明，细胞的表面电荷强烈依赖于其所处的离子介质的性质，其中大多数离子的价态是最重要的因素。当离子强度高时，电荷会急剧下降。另一方面，在酸性 pH 值下，电荷变为零或正电荷，而在碱性 pH 值下，负电荷增加。
