Honegger C G, Krenger W, Langemann H
Neurosci Lett. 1986 Aug 15;69(1):109-14. doi: 10.1016/0304-3940(86)90424-6.
We investigated the effects of chronic relapsing experimental allergic encephalomyelitis (first attack and first recovery) on uric acid (UR) concentrations in Lewis rat spinal cord. Perchloric extracts of 9 regions between spinal cord segments C3 and Co1 were injected into a reversed-phase high-performance liquid chromatographic system, and UR was quantified electrochemically. In all regions UR, which was lower than 0.5 micrograms/g wet tissue in rats injected with adjuvant (controls), increased to a variable extent during the attack (5-12 micrograms/g, maximum in T11-L2) and returned during recovery to a residual level of 1-2 micrograms/g. These findings can be partly attributed to blood-brain barrier damage.
我们研究了慢性复发性实验性变应性脑脊髓炎（首次发作和首次恢复）对Lewis大鼠脊髓中尿酸（UR）浓度的影响。将脊髓C3节段和Co1节段之间9个区域的高氯酸提取物注入反相高效液相色谱系统，并通过电化学方法对UR进行定量。在所有区域中，注射佐剂的大鼠（对照组）湿组织中UR低于0.5微克/克，在发作期间UR不同程度升高（5 - 12微克/克，在T11 - L2节段最高），恢复期间UR降至1 - 2微克/克的残留水平。这些发现部分可归因于血脑屏障损伤。
